Nanoparticle-hydrogel Superstructures for Biomedical Applications

Overview

Journal J Control Release

Specialty Pharmacology

Date 2020 May 29

PMID 32464152

Citations 66

Authors

Yao Jiang

Nishta Krishnan

Jiyoung Heo

Ronnie H Fang

Liangfang Zhang

Affiliations

Soon will be listed here.

Abstract

The incorporation of nanoparticles into hydrogels yields novel superstructures that have become increasingly popular in biomedical research. Each component of these nanoparticle-hydrogel superstructures can be easily modified, resulting in platforms that are highly tunable and inherently multifunctional. The advantages of the nanoparticle and hydrogel constituents can be synergistically combined, enabling these superstructures to excel in scenarios where employing each component separately may have suboptimal outcomes. In this review, the synthesis and fabrication of different nanoparticle-hydrogel superstructures are discussed, followed by an overview of their use in a range of applications, including drug delivery, detoxification, immune modulation, and tissue engineering. Overall, these platforms hold significant clinical potential, and it is envisioned that future development along these lines will lead to unique solutions for addressing areas of pressing medical need.

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