Long Non-coding RNAs in Cutaneous Biology and Keratinocyte Carcinomas

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2020 May 29

PMID 32462404

Citations 14

Authors

Minna Piipponen

Liisa Nissinen

Veli-Matti Kahari

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) are a largely uncharacterized group of non-coding RNAs with diverse regulatory roles in various biological processes. Recent observations have elucidated the functional roles of lncRNAs in cutaneous biology, e.g. in proliferation and differentiation of epidermal keratinocytes and in cutaneous wound repair. Furthermore, the role of lncRNAs in keratinocyte-derived skin cancers is emerging, especially in cutaneous squamous cell carcinoma (cSCC), which presents a significant burden to health care services worldwide and causes high mortality as metastatic disease. Elucidation of the functions of keratinocyte-specific lncRNAs will improve understanding of the molecular pathogenesis of epidermal disorders and skin cancers and can be exploited in development of new diagnostic and therapeutic applications for keratinocyte carcinomas. In this review, we summarize the current evidence of functionally important lncRNAs in cutaneous biology and in keratinocyte carcinomas.

Citing Articles

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Clustering of RNA co-expression network identifies novel long non-coding RNA biomarkers in squamous cell carcinoma.

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Super Enhancer-Regulated () Upregulates the Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma.

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