Dissolved Oxygen from Microalgae-gel Patch Promotes Chronic Wound Healing in Diabetes

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2020 May 23

PMID 32440554

Citations 79

Authors

Huanhuan Chen

Yuhao Cheng

Jingrun Tian

Peizheng Yang

Xuerao Zhang

Yunhao Chen

Yiqiao Hu

Jinhui Wu

Affiliations

Soon will be listed here.

Abstract

Chronic wounds in diabetes undergo a lifetime risk of developing into diabetic foot ulcers. Oxygen is crucial to wound healing by regulating cell proliferation, migration, and neovascularization. However, current oxygen therapies, including hyperbaric oxygen (HBO) and topical gaseous oxygen (TGO), mainly employ gaseous oxygen delivery, which is much less effective in penetrating the skin. Here, we introduce an oxygen-producing patch, made of living microalgae hydrogel, which can produce dissolved oxygen. The superior performance of the patch that results from its dissolved oxygen delivery is >100-fold much more efficient than TGO penetrating the skin. Further experiments indicate that the patch could promote cell proliferation, migration, and tube formation in vitro, and improve chronic wound healing and the survival of skin grafts in diabetic mice. We believe that the microalgae-gel patch can provide continuous dissolved oxygen to improve chronic wound healing.

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