The Powerful Immune System Against Powerful COVID-19: A Hypothesis

Overview

Journal Med Hypotheses

Specialty General Medicine

Date 2020 May 11

PMID 32388390

Citations 55

Authors

Farzad Taghizadeh-Hesary

Hassan Akbari

Affiliations

Soon will be listed here.

Abstract

On March 11, 2020, the World Health Organization declared the coronavirus outbreak a pandemic. Since December 2019, the world has experienced an outbreak of coronavirus disease 2019 (COVID-19). Epidemiology, risk factors, and clinical characteristics of patients with COVID-19 have been reported but the factors affecting the immune system against COVID-19 have not been well described. In this article, we provide a novel hypothesis to describe how an increase in cellular adenosine triphosphate (c-ATP) can potentially improve the efficiency of innate and adaptive immune systems to either prevent or fight off COVID-19.

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References

Channappanavar R, Fehr A, Vijay R, Mack M, Zhao J, Meyerholz D . Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice. Cell Host Microbe. 2016; 19(2):181-93. PMC: 4752723. DOI: 10.1016/j.chom.2016.01.007. View

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z . Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395(10229):1054-1062. PMC: 7270627. DOI: 10.1016/S0140-6736(20)30566-3. View

Perl A, Gergely Jr P, Nagy G, Koncz A, Banki K . Mitochondrial hyperpolarization: a checkpoint of T-cell life, death and autoimmunity. Trends Immunol. 2004; 25(7):360-7. PMC: 4034110. DOI: 10.1016/j.it.2004.05.001. View

Qian F, Wang X, Zhang L, Lin A, Zhao H, Fikrig E . Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J Infect Dis. 2011; 203(10):1415-24. PMC: 3080893. DOI: 10.1093/infdis/jir048. View

Jin J, Bai P, He W, Wu F, Liu X, Han D . Gender Differences in Patients With COVID-19: Focus on Severity and Mortality. Front Public Health. 2020; 8:152. PMC: 7201103. DOI: 10.3389/fpubh.2020.00152. View

Kindler E, Thiel V . SARS-CoV and IFN: Too Little, Too Late. Cell Host Microbe. 2016; 19(2):139-41. PMC: 7104995. DOI: 10.1016/j.chom.2016.01.012. View

Wu Z, McGoogan J . Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020; 323(13):1239-1242. DOI: 10.1001/jama.2020.2648. View

Burelle Y, Hochachka P . Endurance training induces muscle-specific changes in mitochondrial function in skinned muscle fibers. J Appl Physiol (1985). 2002; 92(6):2429-38. DOI: 10.1152/japplphysiol.01024.2001. View

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H . Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020; 395(10224):565-574. PMC: 7159086. DOI: 10.1016/S0140-6736(20)30251-8. View

10.

Seif F, Khoshmirsafa M, Aazami H, Mohsenzadegan M, Sedighi G, Bahar M . The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells. Cell Commun Signal. 2017; 15(1):23. PMC: 5480189. DOI: 10.1186/s12964-017-0177-y. View

11.

Malinska D, Wieckowski M, Michalska B, Drabik K, Prill M, Patalas-Krawczyk P . Mitochondria as a possible target for nicotine action. J Bioenerg Biomembr. 2019; 51(4):259-276. PMC: 6679833. DOI: 10.1007/s10863-019-09800-z. View

12.

de Wit E, van Doremalen N, Falzarano D, Munster V . SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016; 14(8):523-34. PMC: 7097822. DOI: 10.1038/nrmicro.2016.81. View

13.

Desler C, Hansen T, Frederiksen J, Marcker M, Singh K, Rasmussen L . Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?. J Aging Res. 2012; 2012:192503. PMC: 3375017. DOI: 10.1155/2012/192503. View

14.

Cervantes-Barragan L, Zust R, Weber F, Spiegel M, Lang K, Akira S . Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. Blood. 2006; 109(3):1131-7. PMC: 8254533. DOI: 10.1182/blood-2006-05-023770. View

15.

Luoma R, Butler M, Stahlschmidt Z . Plasticity of immunity in response to eating. J Exp Biol. 2016; 219(Pt 13):1965-8. DOI: 10.1242/jeb.138123. View

16.

Kassi E, Moutsatsou P . Estrogen receptor signaling and its relationship to cytokines in systemic lupus erythematosus. J Biomed Biotechnol. 2010; 2010:317452. PMC: 2896666. DOI: 10.1155/2010/317452. View

17.

Zhang C, He H, Wang L, Zhang N, Huang H, Xiong Q . Virus-Triggered ATP Release Limits Viral Replication through Facilitating IFN-β Production in a P2X7-Dependent Manner. J Immunol. 2017; 199(4):1372-1381. DOI: 10.4049/jimmunol.1700187. View

18.

Prompetchara E, Ketloy C, Palaga T . Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pac J Allergy Immunol. 2020; 38(1):1-9. DOI: 10.12932/AP-200220-0772. View

19.

Johnson T, Jinnah H, Kamatani N . Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP. Front Pharmacol. 2019; 10:98. PMC: 6390775. DOI: 10.3389/fphar.2019.00098. View