Control of Coronavirus Infection Through Plasmacytoid Dendritic-cell-derived Type I Interferon

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2006 Sep 21

PMID 16985170

Citations 266

Authors

Luisa Cervantes-Barragan

Roland Zust

Friedemann Weber

Martin Spiegel

Karl S Lang

Shizuo Akira

Volker Thiel

Burkhard Ludewig

Affiliations

Soon will be listed here.

Abstract

This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.

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