Hepatic Ischemia-reperfusion Injury in Liver Transplant Setting: Mechanisms and Protective Strategies

Overview

Journal J Biomed Res

Specialty General Medicine

Date 2020 May 9

PMID 32383437

Citations 51

Authors

Sanketh Rampes

Daqing Ma

Affiliations

Soon will be listed here.

Abstract

Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure, and is of increasing significance due to increased use of expanded criteria livers for transplantation. This review summarizes the mechanisms and protective strategies for hepatic ischemia-reperfusion injury in the context of liver transplantation. Pharmacological therapies, the use of pre-and post-conditioning and machine perfusion are discussed as protective strategies. The use of machine perfusion offers significant potential in the reconditioning of liver grafts and the prevention of hepatic ischemia-reperfusion injury, and is an exciting and active area of research, which needs more study clinically.

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