Modeling Neurodegenerative Disorders in

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 May 3

PMID 32357532

Citations 50

Authors

Harris Bolus

Kassi Crocker

Grace Boekhoff-Falk

Stanislava Chtarbanova

Affiliations

Soon will be listed here.

Abstract

provides a powerful genetic model system in which to investigate the molecular mechanisms underlying neurodegenerative diseases. In this review, we discuss recent progress in modeling Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington's Disease, Ataxia Telangiectasia, and neurodegeneration related to mitochondrial dysfunction or traumatic brain injury. We close by discussing recent progress using models of neural regeneration and how these are likely to provide critical insights into future treatments for neurodegenerative disorders.

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