Two Diterpene Synthases from Chryseobacterium: Chryseodiene Synthase and Wanjudiene Synthase

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2020 Apr 29

PMID 32342621

Citations 8

Authors

Lukas Lauterbach

Bernd Goldfuss

Jeroen S Dickschat

Affiliations

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Abstract

Two bacterial diterpene synthases (DTSs) from Chryseobacterium were characterised. The first enzyme yielded the new compound chryseodiene that closely resembles the known fusicoccane diterpenes from fungi, but its experimentally and computationally studied cyclisation mechanism is fundamentally different to the mechanism of fusicoccadiene synthase. The second enzyme produced wanjudiene, a diterpene hydrocarbon with a new skeleton, besides traces of the enantiomer of bonnadiene that was recently discovered from Allokutzneria albata.

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