Cutoff Point Estimation for Serum Vitamin D Concentrations to Predict Cardiometabolic Risk in Brazilian Children

Overview

Journal Eur J Clin Nutr

Specialty Nutritional Sciences

Date 2020 Apr 29

PMID 32341487

Citations 5

Authors

Luana Cupertino Milagres

Mariana de Santis Filgueiras

Naruna Pereira Rocha

Lara Gomes Suhett

Fernanda Martins de Albuquerque

Leidjaira Lopes Juvanhol

Sylvia do Carmo Castro Franceschini

Juliana Farias de Novaes

Affiliations

Soon will be listed here.

Abstract

Background/objectives: To evaluate serum 25(OH)D concentrations and determine a cutoff point for cardiometabolic risk in children.

Subject/methods: This is a cross-sectional study with a representative sample of 378 8-9-year-old children from all urban schools in the city of Viçosa, MG, Brazil. Sociodemographic data and information on lifestyle, and food consumption were collected. Biochemical evaluation included glucose, triglycerides, leptin, calcidiol [25(OH)D], and parathormone. Body composition was assessed by dual energy X-ray absorptiometry. Cardiometabolic risk was considered when nontraditional risk markers were detected, including triglyceride × glycemia index (TyG index), hyperleptinemia, and hypertriglyceridemic waist phenotype (HWP). The receiver operating characteristic curve (ROC) was used to define the cutoff point for serum 25(OH)D to predict cardiometabolic risk.

Results: 25(OH)D showed better predictive capacity for grouping of cardiometabolic risk markers than for either single or paired markers. The area under the curve for grouping of risk markers was 0.636 (95% CI: 0.585, 0.685, P < 0.001). The cutoff point to predict cardiometabolic risk was defined as 32.0 ng/mL.

Conclusion: 25(OH)D presented good predictive capacity for cardiometabolic risk and 25(OH)D concentration higher than 32 ng/mL was associated with a 49% reduction of cardiometabolic risk prevalence in prepubertal Brazilian children.

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