Pharmacological Targeting of the Actin Cytoskeleton to Drive Endocrinogenesis

Overview

Journal Trends Pharmacol Sci

Specialty Pharmacology

Date 2020 Apr 29

PMID 32340752

Citations 1

Authors

Johanna Siehler

Anna Karolina Blochinger

Heiko Lickert

Affiliations

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Abstract

In vitro generation of insulin-secreting beta cells from human pluripotent stem cells (hPSCs) opens new avenues for treating and modeling diabetes. Hogrebe and colleaguesestablished a new 2D differentiation protocol where they targeted the cytoskeleton pharmacologically for controlled endocrine induction and generation of hPSC-derived beta cells with improved function.

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