3D Printed Laminated CaCO-Nanocellulose Films As Controlled-Release 5-Fluorouracil

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2020 Apr 29

PMID 32340327

Citations 11

Authors

Denesh Mohan

Nur Fatin Khairullah

Yan Ping How

Mohd Shaiful Sajab

Hatika Kaco

Affiliations

Soon will be listed here.

Abstract

Drug delivery constitutes the formulations, technologies, and systems for the transport of pharmaceutical compounds to specific areas in the body to exert safe therapeutic effects. The main criteria for selecting the correct medium for drug delivery are the quantity of the drug being carried and the amount of time required to release the drug. Hence, this research aimed to improve the aforementioned criteria by synthesizing a medium based on calcium carbonate-nanocellulose composite and evaluating its efficiency as a medium for drug delivery. Specifically, the efficiency was assessed in terms of the rates of uptake and release of 5-fluorouracil. Through the evaluation of the morphological and chemical properties of the synthesized composite, the established 3D printing profiles of nanocellulose and CaCO took place following the layer-by-layer films. The 3D printed double laminated CaCO-nanocellulose managed to release the 5-fluorouracil as an effective single composition and in a time-controlled manner.

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