Review of the Diagnosis of Gastrointestinal Lanthanum Deposition

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2020 Apr 21

PMID 32308345

Citations 10

Authors

Masaya Iwamuro

Haruo Urata

Takehiro Tanaka

Hiroyuki Okada

Affiliations

Soon will be listed here.

Abstract

Lanthanum carbonate is used for treatment of hyperphosphatemia mostly in patients with chronic renal failure. Although lanthanum carbonate is safe, recently, lanthanum deposition in the gastrointestinal mucosa of patients has been reported in the literature. This review provides an overview of gastroduodenal lanthanum deposition and focuses on disease's endoscopic, radiological, and histological features, prevalence, and outcome, by reviewing relevant clinical studies, case reports, and basic research findings, to better understand the endoscopic manifestation of gastrointestinal lanthanum deposition. The possible relationship between gastric lanthanum deposition pattern and gastric mucosal atrophy is also illustrated; in patients without gastric mucosal atrophy, gastric lanthanum deposition appears as diffuse white lesions in the posterior wall and lesser curvature of the gastric body. In the gastric mucosa with atrophy, lanthanum-related lesions likely appear as annular or granular whitish lesions. Moreover, these white lesions are probably more frequently observed in the lower part of the stomach, where intestinal metaplasia begins.

Citing Articles

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Drug-induced mucosal alterations observed during esophagogastroduodenoscopy.

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Whitish gastric mucosa on upper gastrointestinal endoscopy.

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The deposition of lanthanum carbonate may activate macrophages to induce gastrointestinal mucosal injury in patients with chronic kidney disease: an in vitro caco-2/THP-1 macrophage coculture model study.

Song Y, Liu H, Yang X J Biol Inorg Chem. 2023; 29(1):101-112.

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A 47-Year-Old Man with Hyperphosphatemia Due to Chronic Renal Failure Treated with Lanthanum Carbonate Tablets Presenting Acutely with Partial Large Bowel Obstruction.

Zhou Q, Yu M, Chang X, Shang S, Li M, Xu W Am J Case Rep. 2023; 24:e942113.

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