Application of Electron Microscopy in Gastroenterology

Overview

Journal World J Gastrointest Pathophysiol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2022 Apr 18

PMID 35433095

Authors

Masaya Iwamuro

Haruo Urata

Takehiro Tanaka

Hiroyuki Okada

Affiliations

Soon will be listed here.

Abstract

Electron microscopy has long been used in research in the fields of life sciences and materials sciences. Transmission and scanning electron microscopy and energy-dispersive X-ray spectroscopy (EDX) analyses have also been performed in the field of gastroenterology. Electron microscopy and EDX enable (1) Observation of ultrastructural differences in esophageal epithelial cells in patients with gastroesophageal reflux and eosinophilic esophagitis; (2) Detection of lanthanum deposition in the stomach and duodenum; (3) Ultrastructural and elemental analyses of enteroliths and bezoars; (4) Detection and characterization of microorganisms in the gastrointestinal tract; (5) Diagnosis of gastrointestinal tumors with neuroendocrine differentiation; and (6) Analysis of gold nanoparticles potentially used in endoscopic photodynamic therapy. This review aims to foster a better understanding of electron microscopy applications by reviewing relevant clinical studies, basic research findings, and the state of current research carried out in gastroenterology science.

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