CircPRRC2A Promotes Angiogenesis and Metastasis Through Epithelial-mesenchymal Transition and Upregulates TRPM3 in Renal Cell Carcinoma

Overview

Journal Theranostics

Date 2020 Apr 16

PMID 32292503

Citations 59

Authors

Wei Li

Feng-Qiang Yang

Chen-Min Sun

Jian-Hua Huang

Hai-Min Zhang

Xue Li

Guang-Chun Wang

Ning Zhang

Jian-Ping Che

Wen-Tao Zhang

Yang Yan

Xu-Dong Yao

Bo Peng

Jun-Hua Zheng

Min Liu

Affiliations

Soon will be listed here.

Abstract

: Circular RNAs (circRNAs) have been identified as essential regulators in a plethora of cancers. Nonetheless, the mechanistic functions of circRNAs in Renal Cell Carcinoma (RCC) remain largely unknown. : In this study, we aimed to identify novel circRNAs that regulate RCC epithelial-mesenchymal transition (EMT), and to subsequently determine their regulatory mechanisms and clinical significance. : circPRRC2A was identified by circRNA microarray and validated by qRT-PCR. The role of circPRRC2A in RCC metastasis was evaluated both and . We found that increased expression of circPRRC2A is positively associated with advanced clinical stage and worse survivorship in RCC patients. Mechanistically, our results indicate that circPRRC2A prevents the degradation of TRPM3, a tissue-specific oncogene, mRNA by sponging miR-514a-5p and miR-6776-5p. Moreover, circPRRC2A promotes tumor EMT and aggressiveness in patients with RCC. : These findings infer the exciting possibility that circPRRC2A may be exploited as a therapeutic and prognostic target for RCC patients.

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