Circular RNAs in Renal Cell Carcinoma: from Mechanistic to Clinical Perspective

Overview

Journal Cancer Cell Int

Publisher Biomed Central

Date 2023 Nov 23

PMID 37993909

Authors

Chunjie Huang

Pooya Esfani Sarafraz

Parisa Enayati

Elham Mortazavi Mamaghani

Emad Babakhanzadeh

Majid Nazari

Affiliations

Soon will be listed here.

Abstract

CircRNAs, a special type of noncoding RNAs characterized by their stable structure and unique abilities to form backsplicing loops, have recently attracted the interest of scientists. These RNAs are abundant throughout the body and play important roles such as microRNA sponges, templates for transcription, and regulation of protein translation and RNA-binding proteins. Renal cancer development is highly correlated with abnormal circRNA expression in vivo. CircRNAs are currently considered promising targets for novel therapeutic approaches as well as possible biomarkers for prognosis and diagnosis of various malignancies. Despite our growing understanding of circRNA, numerous questions remain unanswered. Here, we address the characteristics of circRNAs and their function, focusing in particular on their impact on drug resistance, metabolic processes, metastasis, cell growth, and programmed cell death in renal cancer. In addition, the application of circRNAs as prognostic and diagnostic biomarkers will be discussed.

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Correction: circular RNAs in renal cell carcinoma: from mechanistic to clinical perspective.

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