Advancing Cancer Research and Medicine with Single-Cell Genomics

Overview

Journal Cancer Cell

Publisher Cell Press

Specialty Oncology

Date 2020 Apr 15

PMID 32289270

Citations 137

Authors

Bora Lim

Yiyun Lin

Nicholas Navin

Affiliations

Soon will be listed here.

Abstract

Single-cell sequencing (SCS) has impacted many areas of cancer research and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resistance. The development and refinement of SCS technologies has led to massive reductions in costs, increased cell throughput, and improved reproducibility, paving the way for clinical applications. However, before translational applications can be realized, there are a number of logistical and technical challenges that must be overcome. This review discusses past cancer research studies, emerging technologies, and future clinical applications that are bound to transform cancer medicine.

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