Measure Twice: Promise of Liquid Biopsy in Pediatric High-Grade Gliomas

Overview

Journal Adv Radiat Oncol

Specialty Oncology

Date 2020 Apr 14

PMID 32280814

Citations 4

Authors

Matthew S Dietz

Catherine Z Beach

Ramon Barajas

Michael S Parappilly

Sidharth K Sengupta

Lissa C Baird

Jeremy N Ciporen

Seunggu J Han

Rebecca Loret De Mola

Yoon Jae Cho

Kellie J Nazemi

Shearwood McClelland 3rd

Melissa H Wong

Jerry J Jaboin

Affiliations

Soon will be listed here.

Abstract

Purpose: To review and critique the current state of liquid biopsy in pHGG.

Materials And Methods: Published literature was reviewed for articles related to liquid biopsy in pediatric glioma and adult glioma with a focus on high-grade gliomas.

Results: This review discusses the current state of liquid biomarkers of pHGG and their potential applications for liquid biopsy development.

Conclusions: While nascent, the progress toward identifying circulating analytes of pHGG primes the field of neuro-oncoogy for liquid biopsy development.

Citing Articles

Detection of tumor-derived cell-free DNA in cerebrospinal fluid using a clinically validated targeted sequencing panel for pediatric brain tumors.

Ronsley R, Karvonen K, Cole B, Paulson V, Stevens J, Crotty E J Neurooncol. 2024; 168(2):215-224.

PMID: 38755519 DOI: 10.1007/s11060-024-04645-y.

Therapeutically targeting the unique disease landscape of pediatric high-grade gliomas.

Fernando D, Ahmed A, Williams B Front Oncol. 2024; 14:1347694.

PMID: 38525424 PMC: 10957575. DOI: 10.3389/fonc.2024.1347694.

Liquid biopsy and tumor DNA/RNA detection in the cerebrospinal fluid of patients diagnosed with central nervous system glioma - A review article.

Borba L, Passos G, Oliveira I Surg Neurol Int. 2023; 14:183.

PMID: 37292399 PMC: 10246314. DOI: 10.25259/SNI_52_2023.

Tumor-Educated Platelets: A Review of Current and Potential Applications in Solid Tumors.

Varkey J, Nicolaides T Cureus. 2021; 13(11):e19189.

PMID: 34873529 PMC: 8635758. DOI: 10.7759/cureus.19189.

References

Staedtke V, Dzaye O, Holdhoff M . Actionable molecular biomarkers in primary brain tumors. Trends Cancer. 2017; 2(7):338-349. PMC: 5461965. DOI: 10.1016/j.trecan.2016.06.003. View

Sullivan J, Nahed B, Madden M, Oliveira S, Springer S, Bhere D . Brain tumor cells in circulation are enriched for mesenchymal gene expression. Cancer Discov. 2014; 4(11):1299-309. PMC: 4221467. DOI: 10.1158/2159-8290.CD-14-0471. View

Ogata-Kawata H, Izumiya M, Kurioka D, Honma Y, Yamada Y, Furuta K . Circulating exosomal microRNAs as biomarkers of colon cancer. PLoS One. 2014; 9(4):e92921. PMC: 3976275. DOI: 10.1371/journal.pone.0092921. View

Stone M, Frendel E . The clinical spectrum of light chain myeloma. A study of 35 patients with special reference to the occurrence of amyloidosis. Am J Med. 1975; 58(5):601-19. DOI: 10.1016/0002-9343(75)90496-9. View

Cristofanilli M, Budd G, Ellis M, Stopeck A, Matera J, Miller M . Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med. 2004; 351(8):781-91. DOI: 10.1056/NEJMoa040766. View

Skog J, Wurdinger T, van Rijn S, Meijer D, Gainche L, Sena-Esteves M . Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008; 10(12):1470-6. PMC: 3423894. DOI: 10.1038/ncb1800. View

Arscott W, Tandle A, Zhao S, Shabason J, Gordon I, Schlaff C . Ionizing radiation and glioblastoma exosomes: implications in tumor biology and cell migration. Transl Oncol. 2014; 6(6):638-48. PMC: 3890698. DOI: 10.1593/tlo.13640. View

Bonner E, Bornhorst M, Packer R, Nazarian J . Liquid biopsy for pediatric central nervous system tumors. NPJ Precis Oncol. 2018; 2:29. PMC: 6297139. DOI: 10.1038/s41698-018-0072-z. View

Luga V, Zhang L, Viloria-Petit A, Ogunjimi A, Inanlou M, Chiu E . Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell. 2012; 151(7):1542-56. DOI: 10.1016/j.cell.2012.11.024. View

10.

Goossens N, Nakagawa S, Sun X, Hoshida Y . Cancer biomarker discovery and validation. Transl Cancer Res. 2015; 4(3):256-269. PMC: 4511498. DOI: 10.3978/j.issn.2218-676X.2015.06.04. View

11.

Veldhuijzen van Zanten S, Baugh J, Chaney B, De Jongh D, Sanchez Aliaga E, Barkhof F . Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease. J Neurooncol. 2017; 132(2):255-266. PMC: 5378734. DOI: 10.1007/s11060-016-2363-y. View

12.

de Vrij J, Maas S, Kwappenberg K, Schnoor R, Kleijn A, Dekker L . Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells. Int J Cancer. 2015; 137(7):1630-42. DOI: 10.1002/ijc.29521. View

13.

Theil G, Fischer K, Weber E, Medek R, Hoda R, Lucke K . The Use of a New CellCollector to Isolate Circulating Tumor Cells from the Blood of Patients with Different Stages of Prostate Cancer and Clinical Outcomes - A Proof-of-Concept Study. PLoS One. 2016; 11(8):e0158354. PMC: 4968821. DOI: 10.1371/journal.pone.0158354. View

14.

Kros J, Mustafa D, Dekker L, Sillevis Smitt P, Luider T, Zheng P . Circulating glioma biomarkers. Neuro Oncol. 2014; 17(3):343-60. PMC: 4483097. DOI: 10.1093/neuonc/nou207. View

15.

Shabason J, Sutton D, Kenton O, Guttmann D, Lustig R, Hill-Kayser C . Patterns of Failure for Pediatric Glioblastoma Multiforme Following Radiation Therapy. Pediatr Blood Cancer. 2016; 63(8):1465-7. DOI: 10.1002/pbc.26031. View

16.

Gabrusiewicz K, Li X, Wei J, Hashimoto Y, Marisetty A, Ott M . Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes. Oncoimmunology. 2018; 7(4):e1412909. PMC: 5889290. DOI: 10.1080/2162402X.2017.1412909. View

17.

Zhang L, Zhang S, Yao J, Lowery F, Zhang Q, Huang W . Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015; 527(7576):100-104. PMC: 4819404. DOI: 10.1038/nature15376. View

18.

Wu G, Diaz A, Paugh B, Rankin S, Ju B, Li Y . The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 2014; 46(5):444-450. PMC: 4056452. DOI: 10.1038/ng.2938. View

19.

Hargrave D, Chuang N, Bouffet E . Conventional MRI cannot predict survival in childhood diffuse intrinsic pontine glioma. J Neurooncol. 2007; 86(3):313-9. DOI: 10.1007/s11060-007-9473-5. View

20.

Crocker M, Ashley S, Giddings I, Petrik V, Hardcastle A, Aherne W . Serum angiogenic profile of patients with glioblastoma identifies distinct tumor subtypes and shows that TIMP-1 is a prognostic factor. Neuro Oncol. 2010; 13(1):99-108. PMC: 3018902. DOI: 10.1093/neuonc/noq170. View