Liquid Biopsy for Pediatric Central Nervous System Tumors

Overview

Journal NPJ Precis Oncol

Publisher Springer Nature

Specialty Oncology

Date 2018 Dec 28

PMID 30588509

Citations 24

Authors

Erin R Bonner

Miriam Bornhorst

Roger J Packer

Javad Nazarian

Affiliations

Soon will be listed here.

Abstract

Central nervous system (CNS) tumors are the most common solid tumors in children, and the leading cause of cancer-related death. Over the past decade, molecular profiling has been incorporated into treatment for pediatric CNS tumors, allowing for a more personalized approach to therapy. Through the identification of tumor-specific changes, it is now possible to diagnose, assign a prognostic subgroup, and develop targeted chemotherapeutic treatment plans for many cancer types. The successful incorporation of informative liquid biopsies, where the liquid biome is interrogated for tumor-associated molecular clues, has the potential to greatly complement the precision-based approach to treatment, and ultimately, to improve clinical outcomes for children with CNS tumors. In this article, the current application of liquid biopsy in cancer therapy will be reviewed, as will its potential for the diagnosis and therapeutic monitoring of pediatric CNS tumors.

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References

Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer F, Hesch R . DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 2001; 61(4):1659-65. View

Jackson R, Fuller G, Abi-Said D, Lang F, Gokaslan Z, Shi W . Limitations of stereotactic biopsy in the initial management of gliomas. Neuro Oncol. 2001; 3(3):193-200. PMC: 1920616. DOI: 10.1093/neuonc/3.3.193. View

Zaret K . Micrococcal nuclease analysis of chromatin structure. Curr Protoc Mol Biol. 2008; Chapter 21:Unit 21.1. DOI: 10.1002/0471142727.mb2101s69. View

Diehl F, Schmidt K, Choti M, Romans K, Goodman S, Li M . Circulating mutant DNA to assess tumor dynamics. Nat Med. 2008; 14(9):985-90. PMC: 2820391. DOI: 10.1038/nm.1789. View

Song L, Crawford G . DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells. Cold Spring Harb Protoc. 2010; 2010(2):pdb.prot5384. PMC: 3627383. DOI: 10.1101/pdb.prot5384. View

Schwanhausser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J . Global quantification of mammalian gene expression control. Nature. 2011; 473(7347):337-42. DOI: 10.1038/nature10098. View

Zhai R, Zhao Y, Su L, Cassidy L, Liu G, Christiani D . Genome-wide DNA methylation profiling of cell-free serum DNA in esophageal adenocarcinoma and Barrett esophagus. Neoplasia. 2012; 14(1):29-33. PMC: 3281939. DOI: 10.1593/neo.111626. View

Higgins M, Jelovac D, Barnathan E, Blair B, Slater S, Powers P . Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood. Clin Cancer Res. 2012; 18(12):3462-9. PMC: 3533370. DOI: 10.1158/1078-0432.CCR-11-2696. View

Saratsis A, Yadavilli S, Magge S, Rood B, Perez J, Hill D . Insights into pediatric diffuse intrinsic pontine glioma through proteomic analysis of cerebrospinal fluid. Neuro Oncol. 2012; 14(5):547-60. PMC: 3337313. DOI: 10.1093/neuonc/nos067. View

10.

Teplyuk N, Mollenhauer B, Gabriely G, Giese A, Kim E, Smolsky M . MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity. Neuro Oncol. 2012; 14(6):689-700. PMC: 3367845. DOI: 10.1093/neuonc/nos074. View

11.

Desiderio C, DAngelo L, Rossetti D, Iavarone F, Giardina B, Castagnola M . Cerebrospinal fluid top-down proteomics evidenced the potential biomarker role of LVV- and VV-hemorphin-7 in posterior cranial fossa pediatric brain tumors. Proteomics. 2012; 12(13):2158-66. DOI: 10.1002/pmic.201100499. View

12.

Schilling D, Todenhofer T, Hennenlotter J, Schwentner C, Fehm T, Stenzl A . Isolated, disseminated and circulating tumour cells in prostate cancer. Nat Rev Urol. 2012; 9(8):448-63. DOI: 10.1038/nrurol.2012.136. View

13.

Hughes A, Cichacz Z, Scheck A, Coons S, Johnston S, Stafford P . Immunosignaturing can detect products from molecular markers in brain cancer. PLoS One. 2012; 7(7):e40201. PMC: 3397978. DOI: 10.1371/journal.pone.0040201. View

14.

Zhang J, Wu G, Miller C, Tatevossian R, Dalton J, Tang B . Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet. 2013; 45(6):602-12. PMC: 3727232. DOI: 10.1038/ng.2611. View

15.

Chen W, Balaj L, Liau L, Samuels M, Kotsopoulos S, Maguire C . BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles. Mol Ther Nucleic Acids. 2013; 2:e109. PMC: 3732870. DOI: 10.1038/mtna.2013.28. View

16.

Hindson C, Chevillet J, Briggs H, Gallichotte E, Ruf I, Hindson B . Absolute quantification by droplet digital PCR versus analog real-time PCR. Nat Methods. 2013; 10(10):1003-5. PMC: 4118677. DOI: 10.1038/nmeth.2633. View

17.

Chan K, Jiang P, Chan C, Sun K, Wong J, Hui E . Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing. Proc Natl Acad Sci U S A. 2013; 110(47):18761-8. PMC: 3839703. DOI: 10.1073/pnas.1313995110. View

18.

Manterola L, Guruceaga E, Gallego Perez-Larraya J, Gonzalez-Huarriz M, Jauregui P, Tejada S . A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool. Neuro Oncol. 2014; 16(4):520-7. PMC: 3956347. DOI: 10.1093/neuonc/not218. View

19.

Humphries J, Penno M, Weiland F, Klingler-Hoffmann M, Zuber A, Boussioutas A . Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer. Biochim Biophys Acta. 2014; 1844(5):1051-8. DOI: 10.1016/j.bbapap.2014.01.018. View

20.

Wu G, Diaz A, Paugh B, Rankin S, Ju B, Li Y . The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 2014; 46(5):444-450. PMC: 4056452. DOI: 10.1038/ng.2938. View