Vine Flavone Ameliorates Glutamic Acid-Induced Neurotoxicity Via MAPK Pathways

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2020 Apr 11

PMID 32273948

Citations 5

Authors

Qiang Chu

Yonglu Li

Zheng Hua

Yaxuan Wang

Xin Yu

Ruoyi Jia

Wen Chen

Xiaodong Zheng

Affiliations

Soon will be listed here.

Abstract

Glutamic acid (Glu) is a worldwide flavor enhancer with various positive effects. However, Glu-induced neurotoxicity has been reported less. (TH), a rare herbal plant in China, possesses high medicinal value. More studies paid attention to tuber of TH whereas vine part (THV) attracts fewer focus. In this study, we extracted and purified flavones from THV (THVF), and UPLC-TOF/MS showed THVF was consisted of 3-caffeoylquinic acid, 5-caffeoylquinic acid, quercetin-3-O-rutinoside, and kaempferol-3-O-rutinoside. , Glu caused severe cytotoxicity, genotoxicity, mitochondrial dysfunction, and oxidative damage to rat phaeochromocytoma (PC12) cells. Conversely, THVF attenuated Glu-induced toxicity via MAPK pathways. , the neurotoxicity triggered by Glu restrained the athletic ability in (). The treatment of THVF reversed the situation induced by Glu. In a word, Glu could cause neurotoxicity and THVF owns potential neuroprotective effects both and via MAPK pathways.

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