Reference Values of Hematological and Biochemical Parameters in Young-adult Cynomolgus Monkey () and Rhesus Monkey () Anesthetized with Ketamine Hydrochloride

Overview

Journal Lab Anim Res

Date 2020 Apr 8

PMID 32257895

Citations 26

Authors

Bon-Sang Koo

Dong-Ho Lee

Philyong Kang

Kang-Jin Jeong

Sangil Lee

Kijin Kim

Youngjeon Lee

Jae-Won Huh

Young-Hyun Kim

Sang-Je Park

Yeung Bae Jin

Sun-Uk Kim

Ji-Su Kim

Yeonghoon Son

Sang-Rae Lee

Affiliations

Soon will be listed here.

Abstract

Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematologic and biochemical reference intervals for healthy cynomolgus and rhesus monkeys anesthetized with ketamine hydrochloride. A total of 142 cynomolgus monkeys (28 males and 114 females) and 42 rhesus monkeys (22 males and 20 females) were selected and analyzed in order to examine reference intervals of 20 hematological and 16 biochemical parameters. The effects of sex were also investigated. Reference intervals for hematological and biochemical parameters were separately established by species (cynomolgus and rhesus) and sex (male and female). No sex-related differences were determined in erythrocyte-related parameters for cynomolgus and rhesus monkey housed in indoor laboratory conditions. Alkaline phosphatase and gamma glutamyltransferase were significantly lower in females than males in both cynomolgus and rhesus monkeys aged 48-96 months. The reference values for hematological and biochemical parameters established herein might provide valuable information for researchers using cynomolgus and rhesus monkeys in experimental conditions for biomedical studies.

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