Hematology and Serum Chemistry Values of Sooty Mangabeys (Cercocebus Atys): Comparison with Rhesus Monkeys

Overview

Journal J Med Primatol

Publisher Wiley

Date 2013 Nov 22

PMID 24256341

Citations 4

Authors

P Sharma

L Chennareddi

E Z Greene-Hartsfield

F Villinger

J K Cohen

J G Herndon

Affiliations

Soon will be listed here.

Abstract

Background: The sooty mangabey is a vulnerable West African species that naturally harbors simian immunodeficiency virus (SIV) without pathological symptoms. We present normative hematology and serum chemistry values for this species.

Methods: Hematology analytes from 136 females and 96 males and serum chemistry analytes from 57 females and 26 males were studied.

Results: Values of several analytes fell outside published reference ranges in the rhesus monkey, a laboratory standard for Old World primates. Erythrocyte-related parameters were higher in mangabeys than in rhesus monkeys, while platelet counts were lower. Mangabeys also had higher gamma-glutamyltransferase levels and lower urea nitrogen levels. Males had higher erythrocyte-associated values than females. Albumin, globulin, albumin/globulin ratio, calcium, and creatinine changed with age in patterns similar to those reported for the rhesus monkey.

Conclusions: The unique blood profile of the mangabey should be taken into account in clinical and experimental studies of this species.

Citing Articles

Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey () and rhesus monkey () anesthetized with ketamine hydrochloride.

Koo B, Lee D, Kang P, Jeong K, Lee S, Kim K Lab Anim Res. 2020; 35:7.

PMID: 32257895 PMC: 7081622. DOI: 10.1186/s42826-019-0006-0.

Accuracy of Human and Veterinary Point-of-Care Glucometers for Use in Rhesus Macaques (Macaca mulatta), Sooty Mangabeys (Cercocebus atys), and Chimpanzees (Pan troglodytes).

Clemmons E, Stovall M, Owens D, Scott J, Jones-Wilkes A, Kempf D J Am Assoc Lab Anim Sci. 2016; 55(3):346-53.

PMID: 27177571 PMC: 4865699.

Novel MHC class I full-length allele and haplotype characterization in sooty mangabeys.

Heimbruch K, Karl J, Wiseman R, Dudley D, Johnson Z, Kaur A Immunogenetics. 2015; 67(8):437-45.

PMID: 26009014 PMC: 4498956. DOI: 10.1007/s00251-015-0847-0.

Immunogenetic characterization of a captive colony of sooty mangabeys (Cercocebus atys) used for SIV research.

Smith G, Bauer L, Crane M, Johnson Z J Med Primatol. 2015; 44(2):76-88.

PMID: 25645218 PMC: 4378528. DOI: 10.1111/jmp.12161.

References

Smucny D, Allison D, Ingram D, Roth G, Kemnitz J, Kohama S . Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta). J Med Primatol 30:161-173, 2001. J Med Primatol. 2004; 33(1):48-54. DOI: 10.1111/j.1600-0684.2003.00052.x. View

Pierre P, Sequeira M, Corcoran C, Blevins M, Gee M, Laudenslager M . Hematological and serum biochemical indices in healthy bonnet macaques (Macaca radiata). J Med Primatol. 2011; 40(5):287-93. PMC: 4354958. DOI: 10.1111/j.1600-0684.2011.00466.x. View

Fraser C, CUMMINGS S, Wilkinson S, Neville R, KNOX J, Ho O . Biological variability of 26 clinical chemistry analytes in elderly people. Clin Chem. 1989; 35(5):783-6. View

Herndon J, Tigges J . Hematologic and blood biochemical variables of captive chimpanzees: cross-sectional and longitudinal analyses. Comp Med. 2002; 51(1):60-9. View

VandeWoude S, Apetrei C . Going wild: lessons from naturally occurring T-lymphotropic lentiviruses. Clin Microbiol Rev. 2006; 19(4):728-62. PMC: 1592692. DOI: 10.1128/CMR.00009-06. View

Worobey M, Telfer P, Souquiere S, Hunter M, Coleman C, Metzger M . Island biogeography reveals the deep history of SIV. Science. 2010; 329(5998):1487. DOI: 10.1126/science.1193550. View

Laird N, Ware J . Random-effects models for longitudinal data. Biometrics. 1982; 38(4):963-74. View

Fraser C, Wilkinson S, Neville R, KNOX J, King J, MacWalter R . Biologic variation of common hematologic laboratory quantities in the elderly. Am J Clin Pathol. 1989; 92(4):465-70. DOI: 10.1093/ajcp/92.4.465. View

Silvestri G, Sodora D, Koup R, Paiardini M, ONeil S, McClure H . Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity. 2003; 18(3):441-52. DOI: 10.1016/s1074-7613(03)00060-8. View

10.

Rushton D, Barth J . What is the evidence for gender differences in ferritin and haemoglobin?. Crit Rev Oncol Hematol. 2009; 73(1):1-9. DOI: 10.1016/j.critrevonc.2009.03.010. View

11.

Videan E, Fritz J, Murphy J . Effects of aging on hematology and serum clinical chemistry in chimpanzees (Pan troglodytes). Am J Primatol. 2007; 70(4):327-38. DOI: 10.1002/ajp.20494. View

12.

Pandrea I, Apetrei C . Where the wild things are: pathogenesis of SIV infection in African nonhuman primate hosts. Curr HIV/AIDS Rep. 2010; 7(1):28-36. PMC: 2824118. DOI: 10.1007/s11904-009-0034-8. View

13.

Smucny D, Allison D, Ingram D, Roth G, Kemnitz J, Kohama S . Changes in blood chemistry and hematology variables during aging in captive rhesus macaques (Macaca mulatta). J Med Primatol. 2001; 30(3):161-73. DOI: 10.1111/j.1600-0684.2001.tb00005.x. View

14.

Peinado V, Celdran J, Viscor G, Palomeque J . Hematology and serum chemistry in the white-crowned mangabey (Cercocebus torquatus lunulatus) and in the mandrill (Mandrillus sphinx). J Med Primatol. 1996; 25(4):282-6. DOI: 10.1111/j.1600-0684.1996.tb00211.x. View