Synthesis, Characterization and Photodynamic Activity Against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Apr 5

PMID 32244514

Citations 3

Authors

Ana T P C Gomes

Rosa Fernandes

Carlos F Ribeiro

Joao P C Tome

Maria G P M S Neves

Fernando de C da Silva

Vitor F Ferreira

Jose A S Cavaleiro

Affiliations

Soon will be listed here.

Abstract

Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR and that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.

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