Antitumor Properties of Certain Spirooxindoles Towards Hepatocellular Carcinoma Endowed with Antioxidant Activity

Overview

Journal J Enzyme Inhib Med Chem

Specialty Biochemistry

Date 2020 Mar 27

PMID 32208781

Citations 31

Authors

Sara T Al-Rashood

Ahmed R Hamed

Ghada S Hassan

Hamad M Alkahtani

Abdulrahman A Almehizia

Amal Alharbi

Mohammad M Al-Sanea

Wagdy M Eldehna

Affiliations

Soon will be listed here.

Abstract

In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic compounds. Interestingly, no much attention has been paid to develop spirooxindole derivatives with dual antioxidant and anticancer activities. In this context, a series of spirooxindoles 6a-p was examined for their anticancer effect towards HepG2 hepatocellular carcinoma and PC-3 prostate cancer cell lines. Spirooxindole 6a was found to be an efficient anti-proliferative agent towards both HepG2 and PC-3 cells (IC50 = 6.9 and 11.8 µM, respectively). Afterwards, spirooxindole 6a was assessed for its apoptosis induction potential in HepG2 cells, where its pro-apoptotic impact was approved via the significant elevation in the Bax/Bcl-2 ratio and the expression levels of caspase-3.

Citing Articles

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