Covid-19 Infection and Mortality: a Physiologist's Perspective Enlightening Clinical Features and Plausible Interventional Strategies

Overview

Journal Am J Physiol Lung Cell Mol Physiol

Publisher American Physiological Society

Specialties Cell Biology
Molecular Biology
Physiology
Pulmonary Medicine

Date 2020 Mar 26

PMID 32207983

Citations 45

Authors

Zaid A Abassi

Karl Skorecki

Samuel Noam Heyman

Safa Kinaneh

Zaher Armaly

Affiliations

Soon will be listed here.

Citing Articles

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Expression of SARS-CoV-2-Related Surface Proteins in Non-Small-Cell Lung Cancer Patients and the Influence of Standard of Care Therapy.

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Nutraceutical prospects of against the infectious viruses.

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References

Pesu M, Watford W, Wei L, Xu L, Fuss I, Strober W . T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature. 2008; 455(7210):246-50. PMC: 2758057. DOI: 10.1038/nature07210. View

Keidar S, Gamliel-Lazarovich A, Kaplan M, Pavlotzky E, Hamoud S, Hayek T . Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients. Circ Res. 2005; 97(9):946-53. DOI: 10.1161/01.RES.0000187500.24964.7A. View

Lam van T, Ivanova T, Hardes K, Heindl M, Morty R, Bottcher-Friebertshauser E . Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. ChemMedChem. 2019; 14(6):673-685. DOI: 10.1002/cmdc.201800807. View

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J . Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020; 382(18):1708-1720. PMC: 7092819. DOI: 10.1056/NEJMoa2002032. View

Zhang J, Dong X, Cao Y, Yuan Y, Yang Y, Yan Y . Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020; 75(7):1730-1741. DOI: 10.1111/all.14238. View

Thomas G . Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol. 2002; 3(10):753-66. PMC: 1964754. DOI: 10.1038/nrm934. View

Coutard B, Valle C, de Lamballerie X, Canard B, Seidah N, Decroly E . The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res. 2020; 176:104742. PMC: 7114094. DOI: 10.1016/j.antiviral.2020.104742. View

Karram T, Abbasi A, Keidar S, Golomb E, Hochberg I, Winaver J . Effects of spironolactone and eprosartan on cardiac remodeling and angiotensin-converting enzyme isoforms in rats with experimental heart failure. Am J Physiol Heart Circ Physiol. 2005; 289(4):H1351-8. DOI: 10.1152/ajpheart.01186.2004. View

Iwai M, Horiuchi M . Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis. Hypertens Res. 2009; 32(7):533-6. PMC: 7091931. DOI: 10.1038/hr.2009.74. View

10.

Hallenberger S, Bosch V, Angliker H, Shaw E, Klenk H, Garten W . Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160. Nature. 1992; 360(6402):358-61. DOI: 10.1038/360358a0. View

11.

Santos R, Ferreira A, Simoes E Silva A . Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Exp Physiol. 2008; 93(5):519-27. DOI: 10.1113/expphysiol.2008.042002. View

12.

Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H . Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020; 8(5):475-481. PMC: 7102538. DOI: 10.1016/S2213-2600(20)30079-5. View

13.

Walls A, Park Y, Tortorici M, Wall A, McGuire A, Veesler D . Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell. 2020; 181(2):281-292.e6. PMC: 7102599. DOI: 10.1016/j.cell.2020.02.058. View

14.

Li W, Moore M, Vasilieva N, Sui J, Wong S, Berne M . Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003; 426(6965):450-4. PMC: 7095016. DOI: 10.1038/nature02145. View

15.

Wan Y, Shang J, Graham R, Baric R, Li F . Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol. 2020; 94(7). PMC: 7081895. DOI: 10.1128/JVI.00127-20. View

16.

Ichiki T, Burnett Jr J . Post-transcriptional modification of pro-BNP in heart failure: is glycosylation and circulating furin key for cardiovascular homeostasis?. Eur Heart J. 2014; 35(43):3001-3. DOI: 10.1093/eurheartj/ehu381. View

17.

Ichiki T, Huntley B, Burnett Jr J . BNP molecular forms and processing by the cardiac serine protease corin. Adv Clin Chem. 2013; 61:1-31. PMC: 4522930. DOI: 10.1016/b978-0-12-407680-8.00001-4. View

18.

Hosaka M, Nagahama M, Kim W, Watanabe T, Hatsuzawa K, Ikemizu J . Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway. J Biol Chem. 1991; 266(19):12127-30. View