Flow Rate Variance of a Fully Implantable Pump for the Delivery of Intravenous Treprostinil in Pulmonary Arterial Hypertension

Overview

Journal Pulm Circ

Publisher Wiley

Specialty Pulmonary Medicine

Date 2020 Mar 25

PMID 32206306

Citations 3

Authors

Manuel J Richter

Satenik Harutyunova

Tom Bollmann

Simon Classen

Jan Fuge

Henning Gall

Felix Gerhardt

Hossein A Ghofrani

Hartmut Gunkel

Ekkehard Grunig

Michael Halank

Alexander Heine

Hans Klose

Tobias J Lange

Claus Neurohr

Kai Nickolaus

Christian F Opitz

Stephan Rosenkranz

Hans-Jurgen Seyfarth

Khodr Tello

Ralf Ewert

Karen M Olsson

Affiliations

Soon will be listed here.

Abstract

Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro® pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 09/2018. A relevant flow rate variance is evident after three years; therefore, flow rate monitoring and dose adjustment are mandatory.

Citing Articles

Periprocedural safety and outcome after pump implantation for intravenous treprostinil administration in patients with pulmonary arterial hypertension.

Kamp J, Fuge J, Karsten J, Rumke S, Hoeper M, Park D BMC Pulm Med. 2021; 21(1):164.

PMID: 33992098 PMC: 8126130. DOI: 10.1186/s12890-021-01541-3.

Long-term experience with implantable infusion pumps for intravenous treprostinil in pulmonary arterial hypertension-procedural safety and system-related complications.

Steringer-Mascherbauer R, Lummersdorfer M, Fugger R, Sigmund E, Huber C, Engleder D Pulm Circ. 2020; 10(4):2045894020970830.

PMID: 33299542 PMC: 7711148. DOI: 10.1177/2045894020970830.

Unexpected Acceleration in Treprostinil Delivery Administered by a Lenus Pro® Implantable Pump in Two Patients Treated for Pulmonary Arterial Hypertension.

Kopp G, Hachulla A, Noble S, Bringard A, Soccal P, Beghetti M Front Med (Lausanne). 2020; 7:539707.

PMID: 33195292 PMC: 7662390. DOI: 10.3389/fmed.2020.539707.

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