» Articles » PMID: 32204423

Occupational Exposure of Plastics Workers to Diisononyl Phthalate (DiNP) and Di(2-propylheptyl) Phthalate (DPHP) in Finland

Overview
Publisher MDPI
Date 2020 Mar 25
PMID 32204423
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

The aim of this study was to assess occupational exposure to diisononyl phthalate (DiNP) and di(2-propylheptyl) phthalate (DPHP] in Finland. Four companies took part in the research project: A cable factory, a plastic producing company, a producer of coated textiles, and a tarpaulin producer. The cable factory used DPHP (and occasionally also diisodecyl phthalate, DiDP), the plastic producing company used both DPHP and DiNP, and the latter two companies used DiNP in their production. Exposure was assessed by measuring phthalate metabolites in urine samples (biomonitoring) and by performing air measurements. Low-level occupational exposure to DiNP was observed in the company that produced coated textiles-out of eight workers, one extruder operator was exposed to DiNP at levels exceeding the non-occupationally exposed population background levels. Some workers in the cable factory and the plastics producing company were occupationally exposed to DPHP. Air levels of phthalates were generally low, mostly below the limit of quantification. All phthalate metabolite concentrations were, however, well below the calculated biomonitoring equivalents, which suggests that the health risks related to the exposure are low.

Citing Articles

Global Environmental and Toxicological Data of Emerging Plasticizers: Current Knowledge, Regrettable Substitution Dilemma, Green Solution and Future Perspectives.

Qadeer A, Anis M, Warner G, Potts C, Giovanoulis G, Nasr S Green Chem. 2024; 26(10):5635-5683.

PMID: 39553194 PMC: 11566117. DOI: 10.1039/d3gc03428c.


Isolation of DiNP-Degrading Microbes from the Mouse Colon and the Influence DiNP Exposure Has on the Microbiota, Intestinal Integrity, and Immune Status of the Colon.

Chiu K, Bashir S, Abdel-Hamid A, Clark L, Laws M, Cann I Toxics. 2022; 10(2).

PMID: 35202261 PMC: 8877566. DOI: 10.3390/toxics10020075.


The effects of the phthalate DiNP on reproduction†.

Yang S, Arcanjo R, Nowak R Biol Reprod. 2020; 104(2):305-316.

PMID: 33125036 PMC: 7876666. DOI: 10.1093/biolre/ioaa201.

References
1.
Leng G, Koch H, Gries W, Schutze A, Langsch A, Bruning T . Urinary metabolite excretion after oral dosage of bis(2-propylheptyl) phthalate (DPHP) to five male volunteers--characterization of suitable biomarkers for human biomonitoring. Toxicol Lett. 2014; 231(2):282-8. DOI: 10.1016/j.toxlet.2014.06.035. View

2.
. [Substance monograph for phthalates - New and updated reference and oxidized monoester metabolites in urine of children-and adults. Opinion of the Commission "Human-Biomonitoring" by the Federal Environment Agency]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011; 54(6):770-85. DOI: 10.1007/s00103-011-1278-1. View

3.
Hines C, Hopf N, Deddens J, Silva M, Calafat A . Occupational exposure to diisononyl phthalate (DiNP) in polyvinyl chloride processing operations. Int Arch Occup Environ Health. 2011; 85(3):317-25. DOI: 10.1007/s00420-011-0674-z. View

4.
Porras S, Koponen J, Hartonen M, Kiviranta H, Santonen T . Non-occupational exposure to phthalates in Finland. Toxicol Lett. 2020; 332:107-117. DOI: 10.1016/j.toxlet.2020.06.021. View

5.
Gries W, Ellrich D, Kupper K, Ladermann B, Leng G . Analytical method for the sensitive determination of major di-(2-propylheptyl)-phthalate metabolites in human urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2012; 908:128-36. DOI: 10.1016/j.jchromb.2012.09.019. View