Good Prognosis for Follicular Lymphoma with Estrogen Receptor α-positive Follicular Dendritic Cells

Overview

Journal Hematol Oncol

Specialties Hematology
Oncology

Date 2020 Mar 21

PMID 32196124

Citations 5

Authors

Rintaro Ohe

Hong-Xue Meng

Akane Yamada

Naing Ye Aung

Takanobu Kabasawa

Yuka Tamura

Aya Utsunomiya

Nobuyuki Tamazawa

Ichiro Kawamura

Takumi Kitaoka

Kazushi Suzuki

Ryo Yanagiya

Tomomi Toubai

Kenichi Ishizawa

Mitsunori Yamakawa

Affiliations

Soon will be listed here.

Abstract

Follicular lymphoma (FL) has a meshwork of follicular dendritic cells (FDCs). We previously demonstrated the presence of estrogen receptor alpha (ERα) CD23 FDCs in grades 1-2 FL. The significance of FDCs as a prognostic factor in FL remains unknown. The current study aimed to compare clinicopathological features, including prognosis, between FL with and without ERα FDCs. This study evaluated the clinicopathological significance of ERα expression in 70 FL patients by immunostaining. The presence of ERα mRNA on FDCs from 5 FL patients was confirmed by CD21/ERα double staining (immunohistochemistry and in situ hybridization). We defined patients with frequent ERα expression as the ERα group and those with infrequent ERα expression as the ERα group. Thirty-two patients were assigned to the ERα group (45.7%), and 38 patients were assigned to the ERα group (54.3%). Both overall survival (OS) and progression-free survival (PFS) were significantly better in the ERα group than in the ERα group (OS, log-rank, P = .0465; PFS, log-rank, P = .0336). Moreover, high ERα expression on FDCs was an independent prognostic factor for OS in both the univariate ([hazard ratio] HR, 0.163; P = .0260) and multivariate (HR, 0.050; P = .0188) analyses and for PFS in both the univariate (HR, 0.232; P = .0213) and multivariate (HR, 0.084; P = .0243) analyses. ERα mRNA expression was detected in CD21 FDCs within the neoplastic follicles of FL patients. In conclusion, a neoplastic follicular microenvironment with ERα-positive FDCs might affect the grade and presence of the follicular pattern of FL and improve patient prognosis.

Citing Articles

Molecular Biomarkers in Prediction of High-Grade Transformation and Outcome in Patients with Follicular Lymphoma: A Comprehensive Systemic Review.

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Mechanisms of lymphoma-stromal interactions focusing on tumor-associated macrophages, fibroblastic reticular cells, and follicular dendritic cells.

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Follicular dendritic cell sarcoma.

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The Tumor Microenvironment in Follicular Lymphoma: Its Pro-Malignancy Role with Therapeutic Potential.

Watanabe T Int J Mol Sci. 2021; 22(10).

PMID: 34069564 PMC: 8160856. DOI: 10.3390/ijms22105352.

Good prognosis for follicular lymphoma with estrogen receptor α-positive follicular dendritic cells.

Ohe R, Meng H, Yamada A, Aung N, Kabasawa T, Tamura Y Hematol Oncol. 2020; 38(3):293-300.

PMID: 32196124 PMC: 7496718. DOI: 10.1002/hon.2730.

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