Histone H3 Wild-type DIPG/DMG Overexpressing EZHIP Extend the Spectrum Diffuse Midline Gliomas with PRC2 Inhibition Beyond H3-K27M Mutation

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 2020 Mar 21

PMID 32193787

Citations 68

Authors

David Castel

Thomas Kergrohen

Arnault Tauziede-Espariat

Alan Mackay

Samia Ghermaoui

Emmanuele Lechapt

Stefan M Pfister

Christof M Kramm

Nathalie Boddaert

Thomas Blauwblomme

Stephanie Puget

Kevin Beccaria

Chris Jones

David T W Jones

Pascale Varlet

Jacques Grill

Marie-Anne Debily

Affiliations

Soon will be listed here.

Citing Articles

An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene.

Reisz Z, Pereira R, Nevis S, Mackay A, Bhaw L, Grabovska Y Acta Neuropathol Commun. 2025; 13(1):7.

PMID: 39815339 PMC: 11737243. DOI: 10.1186/s40478-024-01899-5.

Pediatric neuro-oncology: Highlights of the last quarter-century.

Power P, Straehla J, Fangusaro J, Bandopadhayay P, Manoharan N Neoplasia. 2024; 59:101098.

PMID: 39637686 PMC: 11664148. DOI: 10.1016/j.neo.2024.101098.

The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications.

Duan X, Xing Z, Qiao L, Qin S, Zhao X, Gong Y Front Immunol. 2024; 15:1495221.

PMID: 39620228 PMC: 11604627. DOI: 10.3389/fimmu.2024.1495221.

Extracellular Histones Profiles of Pediatric H3K27-Altered Diffuse Midline Glioma.

Buzova D, Petrilli L, Frohlich J, Tsoneva D, Bianco S, Braghini M Mol Diagn Ther. 2024; 29(1):129-141.

PMID: 39514166 DOI: 10.1007/s40291-024-00754-6.

H3K27me3 Loss in Central Nervous System Tumors: Diagnostic, Prognostic, and Therapeutic Implications.

Angelico G, Mazzucchelli M, Attanasio G, Tinnirello G, Farina J, Zanelli M Cancers (Basel). 2024; 16(20).

PMID: 39456545 PMC: 11506073. DOI: 10.3390/cancers16203451.

References

Capper D, Jones D, Sill M, Hovestadt V, Schrimpf D, Sturm D . DNA methylation-based classification of central nervous system tumours. Nature. 2018; 555(7697):469-474. PMC: 6093218. DOI: 10.1038/nature26000. View

Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N . Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. Acta Neuropathol. 2015; 130(6):815-27. PMC: 4654747. DOI: 10.1007/s00401-015-1478-0. View

Castel D, Philippe C, Kergrohen T, Sill M, Merlevede J, Barret E . Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location. Acta Neuropathol Commun. 2018; 6(1):117. PMC: 6219253. DOI: 10.1186/s40478-018-0614-1. View

Jain S, Do T, Lund P, Rashoff A, Diehl K, Cieslik M . PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nat Commun. 2019; 10(1):2146. PMC: 6513997. DOI: 10.1038/s41467-019-09981-6. View

Louis D, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee W . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016; 131(6):803-20. DOI: 10.1007/s00401-016-1545-1. View

Pajtler K, Wen J, Sill M, Lin T, Orisme W, Tang B . Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas. Acta Neuropathol. 2018; 136(2):211-226. PMC: 6105278. DOI: 10.1007/s00401-018-1877-0. View

Panwalkar P, Clark J, Ramaswamy V, Hawes D, Yang F, Dunham C . Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome. Acta Neuropathol. 2017; 134(5):705-714. PMC: 5647236. DOI: 10.1007/s00401-017-1752-4. View

Puget S, Beccaria K, Blauwblomme T, Roujeau T, James S, Grill J . Biopsy in a series of 130 pediatric diffuse intrinsic Pontine gliomas. Childs Nerv Syst. 2015; 31(10):1773-80. DOI: 10.1007/s00381-015-2832-1. View

Robison N, Kieran M . Diffuse intrinsic pontine glioma: a reassessment. J Neurooncol. 2014; 119(1):7-15. DOI: 10.1007/s11060-014-1448-8. View

10.

Sloan E, Cooney T, Oberheim Bush N, Buerki R, Taylor J, Clarke J . Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas. Acta Neuropathol. 2019; 138(5):877-881. PMC: 6818961. DOI: 10.1007/s00401-019-02072-2. View

11.

Tauziede-Espariat A, Debily M, Castel D, Grill J, Puget S, Sabel M . An integrative radiological, histopathological and molecular analysis of pediatric pontine histone-wildtype glioma with MYCN amplification (HGG-MYCN). Acta Neuropathol Commun. 2019; 7(1):87. PMC: 6556947. DOI: 10.1186/s40478-019-0738-y. View

12.

Worst B, van Tilburg C, Balasubramanian G, Fiesel P, Witt R, Freitag A . Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study. Eur J Cancer. 2016; 65:91-101. DOI: 10.1016/j.ejca.2016.06.009. View

13.

South M, Wreghitt T, Caul E . Stevens-Johnson syndrome associated with psittacosis. J Infect. 1985; 11(2):173. DOI: 10.1016/s0163-4453(85)92171-1. View