An Integrative Radiological, Histopathological and Molecular Analysis of Pediatric Pontine Histone-wildtype Glioma with MYCN Amplification (HGG-MYCN)

Overview

Journal Acta Neuropathol Commun

Publisher Biomed Central

Specialty Neurology

Date 2019 Jun 11

PMID 31177990

Citations 20

Authors

A Tauziede-Espariat

M-A Debily

D Castel

J Grill

S Puget

M Sabel

K Blomgren

A Gareton

V Dangouloff-Ros

E Lechapt

N Boddaert

P Varlet

Affiliations

Soon will be listed here.

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References

Sturm D, Orr B, Toprak U, Hovestadt V, Jones D, Capper D . New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs. Cell. 2016; 164(5):1060-1072. PMC: 5139621. DOI: 10.1016/j.cell.2016.01.015. View

Havrda M, Paolella B, Ran C, Jering K, Wray C, Sullivan J . Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment. Cancer Res. 2014; 74(6):1822-32. PMC: 5061294. DOI: 10.1158/0008-5472.CAN-13-1839. View

Calmon R, Puget S, Varlet P, Beccaria K, Blauwblomme T, Grevent D . Multimodal Magnetic Resonance Imaging of Treatment-Induced Changes to Diffuse Infiltrating Pontine Gliomas in Children and Correlation to Patient Progression-Free Survival. Int J Radiat Oncol Biol Phys. 2017; 99(2):476-485. DOI: 10.1016/j.ijrobp.2017.04.007. View

Korshunov A, Schrimpf D, Ryzhova M, Sturm D, Chavez L, Hovestadt V . H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers. Acta Neuropathol. 2017; 134(3):507-516. DOI: 10.1007/s00401-017-1710-1. View

Liu C, Sage J, Miller M, Verhaak R, Hippenmeyer S, Vogel H . Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell. 2011; 146(2):209-21. PMC: 3143261. DOI: 10.1016/j.cell.2011.06.014. View

Wu Y, Liu Y, Levine E, Rao M . Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors. Dev Dyn. 2003; 226(4):675-89. DOI: 10.1002/dvdy.10278. View

Khuong-Quang D, Buczkowicz P, Rakopoulos P, Liu X, Fontebasso A, Bouffet E . K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol. 2012; 124(3):439-47. PMC: 3422615. DOI: 10.1007/s00401-012-0998-0. View

Castel D, Philippe C, Kergrohen T, Sill M, Merlevede J, Barret E . Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location. Acta Neuropathol Commun. 2018; 6(1):117. PMC: 6219253. DOI: 10.1186/s40478-018-0614-1. View

Louis D, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee W . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016; 131(6):803-20. DOI: 10.1007/s00401-016-1545-1. View

10.

Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Letourneau L, Dzamba M . Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nat Genet. 2014; 46(5):451-6. PMC: 3997489. DOI: 10.1038/ng.2936. View

11.

Sturm D, Witt H, Hovestadt V, Khuong-Quang D, Jones D, Konermann C . Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell. 2012; 22(4):425-37. DOI: 10.1016/j.ccr.2012.08.024. View