» Articles » PMID: 32191589

Feasibility and Ethical Issues: Experiences and Concerns of Healthcare Workers Regarding a New RSV Prophylaxis Programme in Nunavik, Quebec

Overview
Date 2020 Mar 20
PMID 32191589
Citations 5
Authors
Affiliations
Soon will be listed here.
Abstract

: The respiratory syncytial virus (RSV) is a major cause of hospitalisation in young Inuit children. Prophylaxis with palivizumab is routinely recommended for premature infants and those with severe pulmonary or cardiac diseases. In the fall 2016, the Quebec Ministry of Health expanded the criteria to include healthy full-term (HFT) newborns from Nunavik based on their high RSV hospitalisation rates.: The aim of this study was to describe the impact of this programme on Nunavik health services during the first RSV season after its implementation (2016-2017) by studying challenges, concerns and needs of healthcare workers (HCWs).: An ethnographic approach was used. Semi-structured interviews focusing on HCWs experiences, and opinions to improve the new programme were conducted with 20 HCWs involved in its implementation.: Main reported challenges and concerns were: additional work(over)load, lack of information and evidence about the need and efficacy of palivizumab in HFT newborns, communication issues between stakeholders, and ethical issues regarding the Inuit population.: The study revealed significant feasibility and acceptability issues. The programme was highly resource consuming. To address HCWs' concerns, evidence-based data regarding palivizumab effectiveness in HFT infants, as well as consultation and involvement of Inuit population are warranted.

Citing Articles

Knowledge and Attitudes Regarding Respiratory Syncytial Virus (RSV) Prevention: A Systematic Review.

Gavaruzzi T, Ceccarelli A, Nanni C, Vignali C, Colonnello V, Caserotti M Vaccines (Basel). 2025; 13(2).

PMID: 40006706 PMC: 11861692. DOI: 10.3390/vaccines13020159.


Cost-effectiveness of nirsevimab and maternal RSVpreF for preventing respiratory syncytial virus disease in infants across Canada.

Bugden S, Mital S, Nguyen H BMC Med. 2025; 23(1):102.

PMID: 39984979 PMC: 11846277. DOI: 10.1186/s12916-025-03928-z.


Infectious diseases in Indigenous populations in North America: learning from the past to create a more equitable future.

Lee N, King A, Vigil D, Mullaney D, Sanderson P, Ametepee T Lancet Infect Dis. 2023; 23(10):e431-e444.

PMID: 37148904 PMC: 10156139. DOI: 10.1016/S1473-3099(23)00190-1.


Urgent air transfers for acute respiratory infections among children from Northern Canada, 2005-2014.

Prendergast C, Robinson J, Caya C, Perez Trejo M, Guan I, Hebert-Murakami V PLoS One. 2022; 17(7):e0272154.

PMID: 35901042 PMC: 9333212. DOI: 10.1371/journal.pone.0272154.


RSV disease in infants and young children: Can we see a brighter future?.

Baraldi E, Lisi G, Costantino C, Heinrichs J, Manzoni P, Ricco M Hum Vaccin Immunother. 2022; 18(4):2079322.

PMID: 35724340 PMC: 9721445. DOI: 10.1080/21645515.2022.2079322.


References
1.
Smylie J, Kirst M, McShane K, Firestone M, Wolfe S, OCampo P . Understanding the role of Indigenous community participation in Indigenous prenatal and infant-toddler health promotion programs in Canada: A realist review. Soc Sci Med. 2016; 150:128-43. DOI: 10.1016/j.socscimed.2015.12.019. View

2.
Singleton R, Dooley L, Bruden D, Raelson S, Butler J . Impact of palivizumab prophylaxis on respiratory syncytial virus hospitalizations in high risk Alaska Native infants. Pediatr Infect Dis J. 2003; 22(6):540-5. DOI: 10.1097/01.inf.0000069768.34383.18. View

3.
Banerji A, Panzov V, Young M, Lee B, Mamdani M, Giles B . The real-life effectiveness of palivizumab for reducing hospital admissions for respiratory syncytial virus in infants residing in Nunavut. Can Respir J. 2013; 21(3):185-9. PMC: 4128465. DOI: 10.1155/2014/941367. View

4.
Singleton R, Bruden D, Brooks L, DeLeon J, Vercelline A, Butler J . Closer to home: local care improves compliance with RSV prophylaxis in high-risk infants. Int J Circumpolar Health. 2006; 65(1):4-7. DOI: 10.3402/ijch.v65i1.17886. View

5.
Kua K, Lee S . Systematic Review of the Safety and Efficacy of Palivizumab among Infants and Young Children with Cystic Fibrosis. Pharmacotherapy. 2017; 37(6):755-769. DOI: 10.1002/phar.1936. View