Treating Severe Wounds in Pediatrics with Medical Grade Honey: A Case Series

Overview

Journal Clin Case Rep

Date 2020 Mar 19

PMID 32185038

Citations 17

Authors

Eleftherios Smaropoulos

Niels A J Cremers

Affiliations

Soon will be listed here.

Abstract

Medical grade honey (MGH) has antimicrobial and pro-healing properties. We here demonstrate that MGH is an easily applicable, safe, and cost-effective approach for severe wounds. The use of MGH should more often be considered to treat all kinds of pediatric wounds.

Citing Articles

Exploring the antibacterial and anti-biofilm activity of two Iranian medical-grade kinds of honey on multidrug-resistant Pseudomonas aeruginosa.

Alshaybawee M, Asgari S, Ghadersoltani P, Mehrabian A, Saniee P BMC Complement Med Ther. 2025; 25(1):39.

PMID: 39905465 PMC: 11792292. DOI: 10.1186/s12906-025-04778-1.

Medical-Grade Honey as a Potential New Therapy for Bacterial Vaginosis.

Lardenoije C, Riel S, Peters L, Wassen M, Cremers N Antibiotics (Basel). 2024; 13(4).

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The impact of wound pH on the antibacterial properties of Medical Grade Honey when applied to bacterial isolates present in common foot and ankle wounds. An in vitro study.

McArdle C, Coyle S, Santos D J Foot Ankle Res. 2023; 16(1):66.

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The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study.

Holubova A, Chlupacova L, Krocova J, Cetlova L, Peters L, Cremers N Antibiotics (Basel). 2023; 12(9).

PMID: 37760661 PMC: 10525154. DOI: 10.3390/antibiotics12091364.

Use of Medical-Grade Honey to Treat Clinically Infected Heel Pressure Ulcers in High-Risk Patients: A Prospective Case Series.

Papanikolaou G, Gousios G, Cremers N Antibiotics (Basel). 2023; 12(3).

PMID: 36978472 PMC: 10044646. DOI: 10.3390/antibiotics12030605.

References

Kateel R, Adhikari P, Augustine A, Ullal S . Topical honey for the treatment of diabetic foot ulcer: A systematic review. Complement Ther Clin Pract. 2016; 24:130-3. DOI: 10.1016/j.ctcp.2016.06.003. View

Doll D, Luedi M, Evers T, Kauf P, Matevossian E . Recurrence-free survival, but not surgical therapy per se, determines 583 patients' long-term satisfaction following primary pilonidal sinus surgery. Int J Colorectal Dis. 2015; 30(5):605-11. DOI: 10.1007/s00384-015-2130-0. View

Saikaly S, Khachemoune A . Honey and Wound Healing: An Update. Am J Clin Dermatol. 2017; 18(2):237-251. DOI: 10.1007/s40257-016-0247-8. View

Boyar V, Handa D, Clemens K, Shimborske D . Clinical experience with Leptospermum honey use for treatment of hard to heal neonatal wounds: case series. J Perinatol. 2014; 34(2):161-3. DOI: 10.1038/jp.2013.158. View

Molan P, Rhodes T . Honey: A Biologic Wound Dressing. Wounds. 2015; 27(6):141-51. View

Pasupuleti V, Sammugam L, Ramesh N, Gan S . Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. Oxid Med Cell Longev. 2017; 2017:1259510. PMC: 5549483. DOI: 10.1155/2017/1259510. View

Weissenstein A, Luchter E, Bittmann S . Medical honey and its role in paediatric patients. Br J Nurs. 2014; 23(6):S30, S32-4. DOI: 10.12968/bjon.2014.23.Sup6.S30. View

Al-Waili N, Salom K, Al-Ghamdi A . Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice. ScientificWorldJournal. 2011; 11:766-87. PMC: 5720113. DOI: 10.1100/tsw.2011.78. View

Minden-Birkenmaier B, Bowlin G . Honey-Based Templates in Wound Healing and Tissue Engineering. Bioengineering (Basel). 2018; 5(2). PMC: 6027142. DOI: 10.3390/bioengineering5020046. View

10.

Ajibola A . Novel Insights into the Health Importance of Natural Honey. Malays J Med Sci. 2017; 22(5):7-22. PMC: 5295738. View

11.

Mohr L, Reyna R, Amaya R . Neonatal case studies using active leptospermum honey. J Wound Ostomy Continence Nurs. 2014; 41(3):213-8. DOI: 10.1097/WON.0000000000000028. View

12.

Bittmann S, Luchter E, Thiel M, Kameda G, Hanano R, Langler A . Does honey have a role in paediatric wound management?. Br J Nurs. 2010; 19(15):S19-20, S22, S24. DOI: 10.12968/bjon.2010.19.Sup5.77704. View

13.

Jull A, Cullum N, Dumville J, Westby M, Deshpande S, Walker N . Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015; (3):CD005083. PMC: 9719456. DOI: 10.1002/14651858.CD005083.pub4. View

14.

Kostogloudis N, Demiri E, Tsimponis A, Dionyssiou D, Ioannidis S, Chatziioannidis I . Severe Extravasation Injuries in Neonates: A Report of 34 Cases. Pediatr Dermatol. 2015; 32(6):830-5. DOI: 10.1111/pde.12664. View

15.

Duncan C, Enlow P, Szabo M, Tolchin E, Kelly R, Castanon L . A Pilot Study of the Efficacy of Active Leptospermum Honey for the Treatment of Partial-Thickness Facial Burns. Adv Skin Wound Care. 2016; 29(8):349-55. DOI: 10.1097/01.ASW.0000484666.83140.b0. View

16.

POSTMES T, van den Bogaard A, Hazen M . The sterilization of honey with cobalt 60 gamma radiation: a study of honey spiked with spores of Clostridium botulinum and Bacillus subtilis. Experientia. 1995; 51(9-10):986-9. DOI: 10.1007/BF01921753. View

17.

Smaropoulos E, Cremers N . Treating severe wounds in pediatrics with medical grade honey: A case series. Clin Case Rep. 2020; 8(3):469-476. PMC: 7069864. DOI: 10.1002/ccr3.2691. View

18.

Krishnamoorthy V, Ramaiah R, Bhananker S . Pediatric burn injuries. Int J Crit Illn Inj Sci. 2012; 2(3):128-34. PMC: 3500004. DOI: 10.4103/2229-5151.100889. View

19.

Cremers N, Belas A, Costa S, Couto I, de Rooster H, Pomba C . In vitro antimicrobial efficacy of two medical grade honey formulations against common high-risk meticillin-resistant staphylococci and Pseudomonas spp. pathogens. Vet Dermatol. 2019; 31(2):90-96. DOI: 10.1111/vde.12811. View

20.

Mandal M, Mandal S . Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2013; 1(2):154-60. PMC: 3609166. DOI: 10.1016/S2221-1691(11)60016-6. View