The Potential Role of Using Vaccine Patches to Induce Immunity: Platform and Pathways to Innovation and Commercialization

Overview

Journal Expert Rev Vaccines

Date 2020 Mar 18

PMID 32182145

Citations 14

Authors

Kamran Badizadegan

James L Goodson

Paul A Rota

Kimberly M Thompson

Affiliations

Soon will be listed here.

Abstract

: In the last two decades, the evidence related to using vaccine patches with multiple short projections (≤1 mm) to deliver vaccines through the skin increased significantly and demonstrated their potential as an innovative delivery platform.: We review the vaccine patch literature published in English as of 1 March 2019, as well as available information from key stakeholders related to vaccine patches as a platform. We identify key research topics related to basic and translational science on skin physical properties and immunobiology, patch development, and vaccine manufacturing.: Currently, vaccine patch developers continue to address some basic science and other platform issues in the context of developing a potential vaccine patch presentation for an existing or new vaccine. Additional clinical data and manufacturing experience could shift the balance toward incentivizing existing vaccine manufactures to further explore the use of vaccine patches to deliver their products. Incentives for innovation of vaccine patches differ for developed and developing countries, which will necessitate different strategies (e.g. public-private partnerships, push, or pull mechanisms) to support the basic and applied research needed to ensure a strong evidence base and to overcome translational barriers for vaccine patches as a delivery platform.

Citing Articles

The Relationship between Immunogenicity and Reactogenicity of Seasonal Influenza Vaccine Using Different Delivery Methods.

Gromer D, Plikaytis B, McCullough M, Wimalasena S, Rouphael N Vaccines (Basel). 2024; 12(7).

PMID: 39066447 PMC: 11281354. DOI: 10.3390/vaccines12070809.

Review of Poliovirus Transmission and Economic Modeling to Support Global Polio Eradication: 2020-2024.

Thompson K, Badizadegan K Pathogens. 2024; 13(6).

PMID: 38921733 PMC: 11206708. DOI: 10.3390/pathogens13060435.

Evaluation of the self-administration potential of high-density microarray patches to human skin: A preliminary study.

Baker B, Hacker E, Siller G, Lee M, Mursaliyev N, Forster A Hum Vaccin Immunother. 2023; 19(1):2189409.

PMID: 36949009 PMC: 10064923. DOI: 10.1080/21645515.2023.2189409.

Evaluation of the Delivery of a Live Attenuated Porcine Reproductive and Respiratory Syndrome Virus as a Unit Solid Dose Injectable Vaccine.

Hayhurst E, Rose E, Pedrera M, Edwards J, Kotynska N, Grainger D Vaccines (Basel). 2022; 10(11).

PMID: 36366345 PMC: 9696641. DOI: 10.3390/vaccines10111836.

Innovations in vaccine delivery: increasing access, coverage, and equity and lessons learnt from measles and rubella elimination.

Goodson J, Rota P Drug Deliv Transl Res. 2022; 12(5):959-967.

PMID: 35211868 PMC: 8870075. DOI: 10.1007/s13346-022-01130-9.

References

Littauer E, Mills L, Brock N, Esser E, Romanyuk A, Pulit-Penaloza J . Stable incorporation of GM-CSF into dissolvable microneedle patch improves skin vaccination against influenza. J Control Release. 2018; 276:1-16. PMC: 5967648. DOI: 10.1016/j.jconrel.2018.02.033. View

Troy S, Kouiavskaia D, Siik J, Kochba E, Beydoun H, Mirochnitchenko O . Comparison of the Immunogenicity of Various Booster Doses of Inactivated Polio Vaccine Delivered Intradermally Versus Intramuscularly to HIV-Infected Adults. J Infect Dis. 2015; 211(12):1969-76. PMC: 4539908. DOI: 10.1093/infdis/jiu841. View

Song J, Kim Y, O E, Compans R, Prausnitz M, Kang S . DNA vaccination in the skin using microneedles improves protection against influenza. Mol Ther. 2012; 20(7):1472-80. PMC: 3392990. DOI: 10.1038/mt.2012.69. View

Matsuo K, Hirobe S, Okada N, Nakagawa S . Frontiers of transcutaneous vaccination systems: novel technologies and devices for vaccine delivery. Vaccine. 2013; 31(19):2403-15. PMC: 7125630. DOI: 10.1016/j.vaccine.2013.03.022. View

Edens C, Collins M, Goodson J, Rota P, Prausnitz M . A microneedle patch containing measles vaccine is immunogenic in non-human primates. Vaccine. 2015; 33(37):4712-8. PMC: 4554796. DOI: 10.1016/j.vaccine.2015.02.074. View

Park S, Lee Y, Kwon Y, Lee Y, Kim K, Ko E . Vaccination by microneedle patch with inactivated respiratory syncytial virus and monophosphoryl lipid A enhances the protective efficacy and diminishes inflammatory disease after challenge. PLoS One. 2018; 13(10):e0205071. PMC: 6203256. DOI: 10.1371/journal.pone.0205071. View

Wang Y, Vlasova A, Velasquez D, Saif L, Kandasamy S, Kochba E . Skin Vaccination against Rotavirus Using Microneedles: Proof of Concept in Gnotobiotic Piglets. PLoS One. 2016; 11(11):e0166038. PMC: 5100943. DOI: 10.1371/journal.pone.0166038. View

Prausnitz M . Engineering Microneedle Patches for Vaccination and Drug Delivery to Skin. Annu Rev Chem Biomol Eng. 2017; 8:177-200. DOI: 10.1146/annurev-chembioeng-060816-101514. View

Deckers J, Hammad H, Hoste E . Langerhans Cells: Sensing the Environment in Health and Disease. Front Immunol. 2018; 9:93. PMC: 5799717. DOI: 10.3389/fimmu.2018.00093. View

10.

Joyce J, Carroll T, Collins M, Chen M, Fritts L, Dutra J . A Microneedle Patch for Measles and Rubella Vaccination Is Immunogenic and Protective in Infant Rhesus Macaques. J Infect Dis. 2018; 218(1):124-132. PMC: 5989599. DOI: 10.1093/infdis/jiy139. View

11.

Kask A, Chen X, Marshak J, Dong L, Saracino M, Chen D . DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge. Vaccine. 2010; 28(47):7483-91. DOI: 10.1016/j.vaccine.2010.09.014. View

12.

Bal S, Kruithof A, Zwier R, Dietz E, Bouwstra J, Lademann J . Influence of microneedle shape on the transport of a fluorescent dye into human skin in vivo. J Control Release. 2010; 147(2):218-24. DOI: 10.1016/j.jconrel.2010.07.104. View

13.

Bonta M, Daina L, Mutiu G . The process of ageing reflected by histological changes in the skin. Rom J Morphol Embryol. 2013; 54(3 Suppl):797-804. View

14.

Kim Y, Quan F, Song J, Vunnava A, Yoo D, Park K . Influenza immunization with trehalose-stabilized virus-like particle vaccine using microneedles. Procedia Vaccinol. 2011; 2(1):15-19. PMC: 3082143. DOI: 10.1016/j.provac.2010.03.004. View

15.

Saitoh A, Aizawa Y . Intradermal vaccination for infants and children. Hum Vaccin Immunother. 2016; 12(9):2447-55. PMC: 5027705. DOI: 10.1080/21645515.2016.1176652. View

16.

Shin J, Park J, Lee D, Quan F, Song C, Kim Y . Microneedle Vaccination Elicits Superior Protection and Antibody Response over Intranasal Vaccination against Swine-Origin Influenza A (H1N1) in Mice. PLoS One. 2015; 10(6):e0130684. PMC: 4472750. DOI: 10.1371/journal.pone.0130684. View

17.

Dean C, Alarcon J, Waterston A, Draper K, Early R, Guirakhoo F . Cutaneous delivery of a live, attenuated chimeric flavivirus vaccine against Japanese encephalitis (ChimeriVax)-JE) in non-human primates. Hum Vaccin. 2006; 1(3):106-11. DOI: 10.4161/hv.1.3.1797. View

18.

Anand A, Zaman K, Estivariz C, Yunus M, Gary H, Weldon W . Early priming with inactivated poliovirus vaccine (IPV) and intradermal fractional dose IPV administered by a microneedle device: A randomized controlled trial. Vaccine. 2015; 33(48):6816-22. PMC: 10423714. DOI: 10.1016/j.vaccine.2015.09.039. View

19.

Jung D, Rejinold N, Kwak J, Park S, Kim Y . Nano-patterning of a stainless steel microneedle surface to improve the dip-coating efficiency of a DNA vaccine and its immune response. Colloids Surf B Biointerfaces. 2017; 159:54-61. DOI: 10.1016/j.colsurfb.2017.07.059. View

20.

Corbett H, Fernando G, Chen X, Frazer I, Kendall M . Skin vaccination against cervical cancer associated human papillomavirus with a novel micro-projection array in a mouse model. PLoS One. 2010; 5(10):e13460. PMC: 2956639. DOI: 10.1371/journal.pone.0013460. View