Hyperscanning: A Valid Method to Study Neural Inter-brain Underpinnings of Social Interaction

Overview

Journal Front Hum Neurosci

Specialty Neurology

Date 2020 Mar 18

PMID 32180710

Citations 113

Authors

Artur Czeszumski

Sara Eustergerling

Anne Lang

David Menrath

Michael Gerstenberger

Susanne Schuberth

Felix Schreiber

Zadkiel Zuluaga Rendon

Peter Konig

Affiliations

Soon will be listed here.

Abstract

Social interactions are a crucial part of human life. Understanding the neural underpinnings of social interactions is a challenging task that the hyperscanning method has been trying to tackle over the last two decades. Here, we review the existing literature and evaluate the current state of the hyperscanning method. We review the type of methods (fMRI, M/EEG, and fNIRS) that are used to measure brain activity from more than one participant simultaneously and weigh their pros and cons for hyperscanning. Further, we discuss different types of analyses that are used to estimate brain networks and synchronization. Lastly, we present results of hyperscanning studies in the context of different cognitive functions and their relations to social interactions. All in all, we aim to comprehensively present methods, analyses, and results from the last 20 years of hyperscanning research.

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References

Babiloni F, Cincotti F, Mattia D, De Vico Fallani F, Tocci A, Bianchi L . High resolution EEG hyperscanning during a card game. Annu Int Conf IEEE Eng Med Biol Soc. 2007; 2007:4957-60. DOI: 10.1109/IEMBS.2007.4353453. View

Novembre G, Knoblich G, Dunne L, Keller P . Interpersonal synchrony enhanced through 20 Hz phase-coupled dual brain stimulation. Soc Cogn Affect Neurosci. 2017; . PMC: 5390732. DOI: 10.1093/scan/nsw172. View

Zhou G, Bourguignon M, Parkkonen L, Hari R . Neural signatures of hand kinematics in leaders vs. followers: A dual-MEG study. Neuroimage. 2015; 125:731-738. PMC: 4692514. DOI: 10.1016/j.neuroimage.2015.11.002. View

Acquadro M, Congedo M, De Riddeer D . Music Performance As an Experimental Approach to Hyperscanning Studies. Front Hum Neurosci. 2016; 10:242. PMC: 4879135. DOI: 10.3389/fnhum.2016.00242. View

Reindl V, Gerloff C, Scharke W, Konrad K . Brain-to-brain synchrony in parent-child dyads and the relationship with emotion regulation revealed by fNIRS-based hyperscanning. Neuroimage. 2018; 178:493-502. DOI: 10.1016/j.neuroimage.2018.05.060. View

Koike T, Tanabe H, Okazaki S, Nakagawa E, Sasaki A, Shimada K . Neural substrates of shared attention as social memory: A hyperscanning functional magnetic resonance imaging study. Neuroimage. 2015; 125:401-412. DOI: 10.1016/j.neuroimage.2015.09.076. View

King-Casas B, Tomlin D, Anen C, Camerer C, Quartz S, Montague P . Getting to know you: reputation and trust in a two-person economic exchange. Science. 2005; 308(5718):78-83. DOI: 10.1126/science.1108062. View

Balconi M, Vanutelli M . Cooperation and Competition with Hyperscanning Methods: Review and Future Application to Emotion Domain. Front Comput Neurosci. 2017; 11:86. PMC: 5627061. DOI: 10.3389/fncom.2017.00086. View

Hirsch J, Zhang X, Adam Noah J, Ono Y . Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact. Neuroimage. 2017; 157:314-330. PMC: 5863547. DOI: 10.1016/j.neuroimage.2017.06.018. View

10.

Koike T, Sumiya M, Nakagawa E, Okazaki S, Sadato N . What Makes Eye Contact Special? Neural Substrates of On-Line Mutual Eye-Gaze: A Hyperscanning fMRI Study. eNeuro. 2019; 6(1). PMC: 6397949. DOI: 10.1523/ENEURO.0284-18.2019. View

11.

Babiloni C, Vecchio F, Infarinato F, Buffo P, Marzano N, Spada D . Simultaneous recording of electroencephalographic data in musicians playing in ensemble. Cortex. 2011; 47(9):1082-90. DOI: 10.1016/j.cortex.2011.05.006. View

12.

Redcay E, Schilbach L . Using second-person neuroscience to elucidate the mechanisms of social interaction. Nat Rev Neurosci. 2019; 20(8):495-505. PMC: 6997943. DOI: 10.1038/s41583-019-0179-4. View

13.

Hirata M, Ikeda T, Kikuchi M, Kimura T, Hiraishi H, Yoshimura Y . Hyperscanning MEG for understanding mother-child cerebral interactions. Front Hum Neurosci. 2014; 8:118. PMC: 3941301. DOI: 10.3389/fnhum.2014.00118. View

14.

Naeem M, Prasad G, Watson D, Kelso J . Functional dissociation of brain rhythms in social coordination. Clin Neurophysiol. 2012; 123(9):1789-97. DOI: 10.1016/j.clinph.2012.02.065. View

15.

Zamm A, Debener S, Bauer A, Bleichner M, Demos A, Palmer C . Amplitude envelope correlations measure synchronous cortical oscillations in performing musicians. Ann N Y Acad Sci. 2018; . DOI: 10.1111/nyas.13738. View

16.

Hu Y, Pan Y, Shi X, Cai Q, Li X, Cheng X . Inter-brain synchrony and cooperation context in interactive decision making. Biol Psychol. 2018; 133:54-62. DOI: 10.1016/j.biopsycho.2017.12.005. View

17.

Stephens G, Silbert L, Hasson U . Speaker-listener neural coupling underlies successful communication. Proc Natl Acad Sci U S A. 2010; 107(32):14425-30. PMC: 2922522. DOI: 10.1073/pnas.1008662107. View

18.

Hu Y, Hu Y, Li X, Pan Y, Cheng X . Brain-to-brain synchronization across two persons predicts mutual prosociality. Soc Cogn Affect Neurosci. 2017; 12(12):1835-1844. PMC: 5716073. DOI: 10.1093/scan/nsx118. View

19.

Burgess A . On the interpretation of synchronization in EEG hyperscanning studies: a cautionary note. Front Hum Neurosci. 2014; 7:881. PMC: 3870947. DOI: 10.3389/fnhum.2013.00881. View

20.

Nguyen T, Schleihauf H, Kayhan E, Matthes D, Vrticka P, Hoehl S . The effects of interaction quality on neural synchrony during mother-child problem solving. Cortex. 2020; 124:235-249. DOI: 10.1016/j.cortex.2019.11.020. View