A Targeted Approach by High Resolution Mass Spectrometry to Reveal New Compounds in Raisins

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Mar 18

PMID 32178240

Citations 3

Authors

Danilo Escobar-Avello

Alexandra Olmo-Cunillera

Julian Lozano-Castellon

Maria Marhuenda-Munoz

Anna Vallverdu-Queralt

Affiliations

Soon will be listed here.

Abstract

Raisins are dried grapes mostly obtained from cultivars of L. and are extensively consumed worldwide. They are rich in bioactive compounds such as polyphenols, which are associated with a broad range of health benefits. The aim of the present study was to compare the phenolic profiles of three different raisin varieties (Thompson seedless, Muscat, and sultanas). Total polyphenols (TPs) were evaluated by the Folin-Ciocalteu (F-C) assay and significant differences were observed among all raisin varieties. Furthermore, liquid chromatography coupled with electrospray ionization hybrid linear ion trap quadrupole-Orbitrap-mass spectrometry (LC/ESI-LTQ-Orbitrap-MS) was employed for the comprehensive identification of phenolic constituents. A total of 45 compounds were identified, including hydroxybenzoic and hydroxycinnamic acids, flavanoids, flavonoids, flavonols, flavones, and stilbenoids. The three varieties of raisins showed a similar phenolic profile, although the highest number of phenolic compounds was identified in Muscat raisins owing to the proanthocyanidins extracted from their seeds, while stilbenoids were not detected in the Thompson variety.

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References

Vallverdu-Queralt A, Arranz S, Medina-Remon A, Casals-Ribes I, Lamuela-Raventos R . Changes in phenolic content of tomato products during storage. J Agric Food Chem. 2011; 59(17):9358-65. DOI: 10.1021/jf202140j. View

Olivati C, de Oliveira Nishiyama Y, de Souza R, Soares Janzantti N, Mauro M, Gomes E . Effect of the pre-treatment and the drying process on the phenolic composition of raisins produced with a seedless Brazilian grape cultivar. Food Res Int. 2019; 116:190-199. DOI: 10.1016/j.foodres.2018.08.012. View

Saez V, Riquelme S, von Baer D, Vallverdu-Queralt A . Phenolic Profile of Grape Canes: Novel Compounds Identified by LC-ESI-LTQ-Orbitrap-MS. Molecules. 2019; 24(20). PMC: 6832258. DOI: 10.3390/molecules24203763. View

Parker T, Wang X, Pazmino J, Engeseth N . Antioxidant capacity and phenolic content of grapes, sun-dried raisins, and golden raisins and their effect on ex vivo serum antioxidant capacity. J Agric Food Chem. 2007; 55(21):8472-7. DOI: 10.1021/jf071468p. View

Quifer-Rada P, Vallverdu-Queralt A, Martinez-Huelamo M, Chiva-Blanch G, Jauregui O, Estruch R . A comprehensive characterisation of beer polyphenols by high resolution mass spectrometry (LC-ESI-LTQ-Orbitrap-MS). Food Chem. 2014; 169:336-43. DOI: 10.1016/j.foodchem.2014.07.154. View

Mena P, Calani L, DallAsta C, Galaverna G, Garcia-Viguera C, Bruni R . Rapid and comprehensive evaluation of (poly)phenolic compounds in pomegranate (Punica granatum L.) juice by UHPLC-MSn. Molecules. 2013; 17(12):14821-40. PMC: 6268091. DOI: 10.3390/molecules171214821. View

Vallverdu-Queralt A, Jauregui O, Di Lecce G, Andres-Lacueva C, Lamuela-Raventos R . Screening of the polyphenol content of tomato-based products through accurate-mass spectrometry (HPLC-ESI-QTOF). Food Chem. 2014; 129(3):877-83. DOI: 10.1016/j.foodchem.2011.05.038. View

Panagopoulou E, Chiou A, Nikolidaki E, Christea M, Karathanos V . Corinthian raisins (Vitis vinifera L., var. Apyrena) antioxidant and sugar content as affected by the drying process: a 3-year study. J Sci Food Agric. 2018; 99(2):915-922. DOI: 10.1002/jsfa.9263. View

Olmo-Cunillera A, Escobar-Avello D, Perez A, Marhuenda-Munoz M, Lamuela-Raventos R, Vallverdu-Queralt A . Is Eating Raisins Healthy?. Nutrients. 2019; 12(1). PMC: 7019280. DOI: 10.3390/nu12010054. View

10.

Serratosa M, Lopez-Toledano A, Merida J, Medina M . Changes in color and phenolic compounds during the raisining of grape cv. Pedro Ximenez. J Agric Food Chem. 2008; 56(8):2810-6. DOI: 10.1021/jf073278k. View

11.

Vallverdu-Queralt A, Lamuela-Raventos R . Foodomics: A new tool to differentiate between organic and conventional foods. Electrophoresis. 2015; 37(13):1784-94. DOI: 10.1002/elps.201500348. View

12.

Mena P, Cirlini M, Tassotti M, Herrlinger K, DallAsta C, Del Rio D . Phytochemical Profiling of Flavonoids, Phenolic Acids, Terpenoids, and Volatile Fraction of a Rosemary (Rosmarinus officinalis L.) Extract. Molecules. 2016; 21(11). PMC: 6273513. DOI: 10.3390/molecules21111576. View

13.

Simirgiotis M, Quispe C, Borquez J, Areche C, Sepulveda B . Fast Detection of Phenolic Compounds in Extracts of Easter Pears (Pyrus communis) from the Atacama Desert by Ultrahigh-Performance Liquid Chromatography and Mass Spectrometry (UHPLC-Q/Orbitrap/MS/MS). Molecules. 2016; 21(1):92. PMC: 6273977. DOI: 10.3390/molecules21010092. View

14.

Vallverdu-Queralt A, Meudec E, Eder M, Lamuela-Raventos R, Sommerer N, Cheynier V . Targeted filtering reduces the complexity of UHPLC-Orbitrap-HRMS data to decipher polyphenol polymerization. Food Chem. 2017; 227:255-263. DOI: 10.1016/j.foodchem.2017.01.106. View

15.

Regueiro J, Sanchez-Gonzalez C, Vallverdu-Queralt A, Simal-Gandara J, Lamuela-Raventos R, Izquierdo-Pulido M . Comprehensive identification of walnut polyphenols by liquid chromatography coupled to linear ion trap-Orbitrap mass spectrometry. Food Chem. 2014; 152:340-8. DOI: 10.1016/j.foodchem.2013.11.158. View

16.

Barreca D, Gattuso G, Bellocco E, Calderaro A, Trombetta D, Smeriglio A . Flavanones: Citrus phytochemical with health-promoting properties. Biofactors. 2017; 43(4):495-506. DOI: 10.1002/biof.1363. View

17.

Ramirez-Garza S, Laveriano-Santos E, Marhuenda-Munoz M, Storniolo C, Tresserra-Rimbau A, Vallverdu-Queralt A . Health Effects of Resveratrol: Results from Human Intervention Trials. Nutrients. 2018; 10(12). PMC: 6317057. DOI: 10.3390/nu10121892. View

18.

Vallverdu-Queralt A, Meudec E, Eder M, Lamuela-Raventos R, Sommerer N, Cheynier V . The Hidden Face of Wine Polyphenol Polymerization Highlighted by High-Resolution Mass Spectrometry. ChemistryOpen. 2017; 6(3):336-339. PMC: 5474658. DOI: 10.1002/open.201700044. View

19.

Rodriguez-Perez C, Garcia-Villanova B, Guerra-Hernandez E, Verardo V . Grape Seeds Proanthocyanidins: An Overview of In Vivo Bioactivity in Animal Models. Nutrients. 2019; 11(10). PMC: 6835351. DOI: 10.3390/nu11102435. View

20.

Gorena T, Saez V, Mardones C, Vergara C, Winterhalter P, von Baer D . Influence of post-pruning storage on stilbenoid levels in Vitis vinifera L. canes. Food Chem. 2014; 155:256-63. DOI: 10.1016/j.foodchem.2014.01.073. View