Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2020 Mar 16

PMID 32172346

Citations 15

Authors

Dan Liu

Yurong Tan

Ousman Bajinka

Lili Wang

Zhongxiang Tang

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Bronchial asthma is a common respiratory disease induced by immune imbalance, characterized by chronic non-specific airway inflammation and airway hyperresponsiveness (AHR). Many factors induce asthma, among which respiratory infection is the important cause. In this review, we discuss how respiratory microbes participate in the occurrence and progression of asthma via Th17/IL-17 axis.

Recent Findings: Pathogenesis of asthma has been considered as closely related to the imbalance in number and function of Th1/Th2 in the CD4 T lymphocyte subsets. Recent studies have shown that Th17 cell and its secretory IL-17 also play an important role in AHR. Respiratory virus, bacteria, fungi, and other respiratory microbial infections can directly or indirectly induce the differentiation of Th17 cell and the production of related cytokines to induce AHR. Respiratory microbial infection can affect the TH17/IL-17A axis through a variety of mechanisms, thereby promoting the occurrence and development of asthma, and these specific mechanisms may provide new effective therapeutic ideas for asthma.

Citing Articles

Impact of Interleukin-17 Receptor A Gene Variants on Asthma Susceptibility and Clinical Manifestations in Children and Adolescents.

Maher S, AbdAllah N, Al Ageeli E, Riad E, Kattan S, Abdelaal S Children (Basel). 2024; 11(6).

PMID: 38929236 PMC: 11202101. DOI: 10.3390/children11060657.

Chalcone-derivative L6H21 attenuates the OVA-induced asthma by targeting MD2.

Ge X, Xu T, Wang M, Gao L, Tang Y, Zhang N Eur J Med Res. 2024; 29(1):65.

PMID: 38245791 PMC: 10799361. DOI: 10.1186/s40001-023-01630-5.

Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease.

Donald K, Finlay B Nat Rev Immunol. 2023; 23(11):735-748.

PMID: 37138015 DOI: 10.1038/s41577-023-00874-w.

The gut microbiota pathway mechanisms of diabetes.

Bajinka O, Tan Y, Darboe A, Ighaede-Edwards I, Abdelhalim K AMB Express. 2023; 13(1):16.

PMID: 36754883 PMC: 9908804. DOI: 10.1186/s13568-023-01520-3.

Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma.

Luo W, Hu J, Xu W, Dong J Front Immunol. 2022; 13:974066.

PMID: 36032162 PMC: 9411752. DOI: 10.3389/fimmu.2022.974066.

References

Bera M, Lu B, Martin T, Cui S, Rhein L, Gerard C . Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. J Immunol. 2011; 187(8):4245-55. PMC: 3186836. DOI: 10.4049/jimmunol.1101789. View

Masoli M, Fabian D, Holt S, Beasley R . The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004; 59(5):469-78. DOI: 10.1111/j.1398-9995.2004.00526.x. View

Bisgaard H, Hermansen M, Buchvald F, Loland L, Halkjaer L, Bonnelykke K . Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med. 2007; 357(15):1487-95. DOI: 10.1056/NEJMoa052632. View

Wang J, Kong L, Luo Q, Li B, Wu J, Liu B . Dual effects of respiratory syncytial virus infections on airway inflammation by regulation of Th17/Treg responses in ovalbumin-challenged mice. Inflammation. 2014; 37(6):1984-2005. DOI: 10.1007/s10753-014-9931-0. View

Wang G, Qian P, Jackson F, Qian G, Wu G . Sequential activation of JAKs, STATs and xanthine dehydrogenase/oxidase by hypoxia in lung microvascular endothelial cells. Int J Biochem Cell Biol. 2007; 40(3):461-70. PMC: 2276459. DOI: 10.1016/j.biocel.2007.08.008. View

Miossec P, Kolls J . Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov. 2012; 11(10):763-76. DOI: 10.1038/nrd3794. View

Essilfie A, Simpson J, Horvat J, Preston J, Dunkley M, Foster P . Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease. PLoS Pathog. 2011; 7(10):e1002244. PMC: 3188527. DOI: 10.1371/journal.ppat.1002244. View

Kassisse E, Garcia H, Prada L, Salazar I, Kassisse J . Prevalence of Mycoplasma pneumoniae infection in pediatric patients with acute asthma exacerbation. Arch Argent Pediatr. 2018; 116(3):179-185. DOI: 10.5546/aap.2018.eng.179. View

Ivanov I, McKenzie B, Zhou L, Tadokoro C, Lepelley A, Lafaille J . The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006; 126(6):1121-33. DOI: 10.1016/j.cell.2006.07.035. View

10.

Tarancon R, Uranga S, Martin C, Aguilo N . Mycobacterium tuberculosis infection prevents asthma and abrogates eosinophilopoiesis in an experimental model. Allergy. 2019; 74(12):2512-2514. DOI: 10.1111/all.13923. View

11.

Thorburn A, Brown A, Nair P, Chevalier N, Foster P, Gibson P . Pneumococcal components induce regulatory T cells that attenuate the development of allergic airways disease by deviating and suppressing the immune response to allergen. J Immunol. 2013; 191(8):4112-20. DOI: 10.4049/jimmunol.1201232. View

12.

Qin L, Tan Y, Hu C, Liu X, He R . Leptin Is Oversecreted by Respiratory Syncytial Virus-Infected Bronchial Epithelial Cells and Regulates Th2 and Th17 Cell Differentiation. Int Arch Allergy Immunol. 2015; 167(1):65-71. DOI: 10.1159/000436966. View

13.

Kong X, San Juan H, Kumar M, Behera A, Mohapatra A, Hellermann G . Respiratory syncytial virus infection activates STAT signaling in human epithelial cells. Biochem Biophys Res Commun. 2003; 306(2):616-22. DOI: 10.1016/s0006-291x(03)01008-8. View

14.

Bush A, Fleming L . Diagnosis and management of asthma in children. BMJ. 2015; 350:h996. DOI: 10.1136/bmj.h996. View

15.

Wakashin H, Hirose K, Maezawa Y, Kagami S, Suto A, Watanabe N . IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice. Am J Respir Crit Care Med. 2008; 178(10):1023-32. DOI: 10.1164/rccm.200801-086OC. View

16.

Wilson N, Boniface K, Chan J, McKenzie B, Blumenschein W, Mattson J . Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol. 2007; 8(9):950-7. DOI: 10.1038/ni1497. View

17.

Shi T, He Y, Sun W, Wu Y, Li L, Jie Z . Respiratory Syncytial virus infection compromises asthma tolerance by recruiting interleukin-17A-producing cells via CCR6-CCL20 signaling. Mol Immunol. 2017; 88:45-57. DOI: 10.1016/j.molimm.2017.05.017. View

18.

Cho M, Kang J, Moon Y, Nam H, Jhun J, Heo S . STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J Immunol. 2006; 176(9):5652-61. DOI: 10.4049/jimmunol.176.9.5652. View

19.

Feng J, Hu Y, Song Z, Liu Y, Guo X, Jie Z . Interleukin-23 facilitates Th1 and Th2 cell differentiation in vitro following respiratory syncytial virus infection. J Med Virol. 2015; 87(4):708-15. DOI: 10.1002/jmv.24126. View

20.

Chu H, Honour J, Rawlinson C, Harbeck R, Martin R . Effects of respiratory Mycoplasma pneumoniae infection on allergen-induced bronchial hyperresponsiveness and lung inflammation in mice. Infect Immun. 2003; 71(3):1520-6. PMC: 148884. DOI: 10.1128/IAI.71.3.1520-1526.2003. View