A Critical Role for Plasminogen in Inflammation

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2020 Mar 12

PMID 32159743

Citations 57

Authors

Sarah K Baker

Sidney Strickland

Affiliations

Soon will be listed here.

Abstract

Plasminogen and its active form, plasmin, have diverse functions related to the inflammatory response in mammals. Due to these roles in inflammation, plasminogen has been implicated in the progression of a wide range of diseases with an inflammatory component. In this review, we discuss the functions of plasminogen in inflammatory regulation and how this system plays a role in the pathogenesis of diseases spanning organ systems throughout the body.

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References

Davalos D, Akassoglou K . Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol. 2011; 34(1):43-62. DOI: 10.1007/s00281-011-0290-8. View

Shaw M, Gao Z, McElhinney K, Thornton S, Flick M, Lane A . Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease. J Neurosci. 2017; 37(14):3776-3788. PMC: 5394895. DOI: 10.1523/JNEUROSCI.2932-15.2017. View

Gissler H, Frank R, Kramer M . Immunohistochemical characterization of the plasminogen activator system in psoriatic epidermis. Br J Dermatol. 1993; 128(6):612-8. DOI: 10.1111/j.1365-2133.1993.tb00254.x. View

Diaz-Ramos A, Roig-Borrellas A, Garcia-Melero A, Llorens A, Lopez-Alemany R . Requirement of plasminogen binding to its cell-surface receptor α-enolase for efficient regeneration of normal and dystrophic skeletal muscle. PLoS One. 2012; 7(12):e50477. PMC: 3519827. DOI: 10.1371/journal.pone.0050477. View

Saido T, Leissring M . Proteolytic degradation of amyloid β-protein. Cold Spring Harb Perspect Med. 2012; 2(6):a006379. PMC: 3367539. DOI: 10.1101/cshperspect.a006379. View

Paul J, Strickland S, Melchor J . Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med. 2007; 204(8):1999-2008. PMC: 2118680. DOI: 10.1084/jem.20070304. View

Flick M, Bugge T . Plasminogen-receptor : plasminogen activation and beyond. J Thromb Haemost. 2016; 15(1):150-154. PMC: 5280338. DOI: 10.1111/jth.13541. View

Onodera H, Nakashima I, Fujihara K, Nagata T, Itoyama Y . Elevated plasma level of plasminogen activator inhibitor-1 (PAI-1) in patients with relapsing-remitting multiple sclerosis. Tohoku J Exp Med. 2000; 189(4):259-65. DOI: 10.1620/tjem.189.259. View

Hudson N . Biophysical Mechanisms Mediating Fibrin Fiber Lysis. Biomed Res Int. 2017; 2017:2748340. PMC: 5467299. DOI: 10.1155/2017/2748340. View

10.

Peetermans M, Vanassche T, Liesenborghs L, Claes J, Velde G, Kwiecinksi J . Plasminogen activation by staphylokinase enhances local spreading of S. aureus in skin infections. BMC Microbiol. 2014; 14:310. PMC: 4274676. DOI: 10.1186/s12866-014-0310-7. View

11.

Mingers A, HEIMBURGER N, Zeitler P, Kreth H, Schuster V . Homozygous type I plasminogen deficiency. Semin Thromb Hemost. 1997; 23(3):259-69. DOI: 10.1055/s-2007-996099. View

12.

Gebbia J, Monco J, Degen J, Bugge T, Benach J . The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis. J Clin Invest. 1999; 103(1):81-7. PMC: 407868. DOI: 10.1172/JCI5171. View

13.

Chen Z, Strickland S . Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell. 1998; 91(7):917-25. DOI: 10.1016/s0092-8674(00)80483-3. View

14.

Li J, Ny A, Leonardsson G, Nandakumar K, Holmdahl R, Ny T . The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis. Am J Pathol. 2005; 166(3):783-92. PMC: 1602367. DOI: 10.1016/S0002-9440(10)62299-7. View

15.

Tsirka S, Bugge T, Degen J, Strickland S . Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin. Proc Natl Acad Sci U S A. 1997; 94(18):9779-81. PMC: 23267. DOI: 10.1073/pnas.94.18.9779. View

16.

Yepes M, Roussel B, Ali C, Vivien D . Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic. Trends Neurosci. 2008; 32(1):48-55. DOI: 10.1016/j.tins.2008.09.006. View

17.

Ceremuga I, Seweryn E, Bednarz-Misa I, Pietkiewicz J, Jermakow K, Banas T . Enolase-like protein present on the outer membrane of Pseudomonas aeruginosa binds plasminogen. Folia Microbiol (Praha). 2014; 59(5):391-7. PMC: 4133640. DOI: 10.1007/s12223-014-0311-9. View

18.

Das R, Pluskota E, Plow E . Plasminogen and its receptors as regulators of cardiovascular inflammatory responses. Trends Cardiovasc Med. 2011; 20(4):120-4. PMC: 3053126. DOI: 10.1016/j.tcm.2010.10.002. View

19.

Engstrom G, Zoller B, Svensson P, Melander O, Persson M . Soluble urokinase plasminogen activator receptor and incidence of venous thromboembolism. Thromb Haemost. 2015; 115(3):657-62. DOI: 10.1160/TH15-06-0511. View

20.

Aoki N, Moroi M, Sakata Y, Yoshida N, Matsuda M . Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis. J Clin Invest. 1978; 61(5):1186-95. PMC: 372639. DOI: 10.1172/JCI109034. View