Poly(N-isopropylacrylamide)-Based Thermoresponsive Composite Hydrogels for Biomedical Applications

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2020 Mar 11

PMID 32150904

Citations 72

Authors

Xiaomin Xu

Yang Liu

Wenbo Fu

Mingyu Yao

Zhen Ding

Jiaming Xuan

Dongxiang Li

Shengjie Wang

Yongqing Xia

Meiwen Cao

Affiliations

Soon will be listed here.

Abstract

Poly(N-isopropylacrylamide) (PNIPAM)-based thermosensitive hydrogels demonstrate great potential in biomedical applications. However, they have inherent drawbacks such as low mechanical strength, limited drug loading capacity and low biodegradability. Formulating PNIPAM with other functional components to form composited hydrogels is an effective strategy to make up for these deficiencies, which can greatly benefit their practical applications. This review seeks to provide a comprehensive observation about the PNIPAM-based composite hydrogels for biomedical applications so as to guide related research. It covers the general principles from the materials choice to the hybridization strategies as well as the performance improvement by focusing on several application areas including drug delivery, tissue engineering and wound dressing. The most effective strategies include incorporation of functional inorganic nanoparticles or self-assembled structures to give composite hydrogels and linking PNIPAM with other polymer blocks of unique properties to produce copolymeric hydrogels, which can improve the properties of the hydrogels by enhancing the mechanical strength, giving higher biocompatibility and biodegradability, introducing multi-stimuli responsibility, enabling higher drug loading capacity as well as controlled release. These aspects will be of great help for promoting the development of PNIPAM-based composite materials for biomedical applications.

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References

Campbell S, Patenaude M, Hoare T . Injectable superparamagnets: highly elastic and degradable poly(N-isopropylacrylamide)-superparamagnetic iron oxide nanoparticle (SPION) composite hydrogels. Biomacromolecules. 2013; 14(3):644-53. DOI: 10.1021/bm301703x. View

Place E, George J, Williams C, Stevens M . Synthetic polymer scaffolds for tissue engineering. Chem Soc Rev. 2009; 38(4):1139-51. DOI: 10.1039/b811392k. View

Jalili N, Muscarello M, Gaharwar A . Nanoengineered thermoresponsive magnetic hydrogels for biomedical applications. Bioeng Transl Med. 2018; 1(3):297-305. PMC: 5689536. DOI: 10.1002/btm2.10034. View

Schreml S, Szeimies R, Prantl L, Landthaler M, Babilas P . Wound healing in the 21st century. J Am Acad Dermatol. 2010; 63(5):866-81. DOI: 10.1016/j.jaad.2009.10.048. View

Graham S, Facal Marina P, Blencowe A . Thermoresponsive polysaccharides and their thermoreversible physical hydrogel networks. Carbohydr Polym. 2019; 207:143-159. DOI: 10.1016/j.carbpol.2018.11.053. View

Thoniyot P, Tan M, Abdul Karim A, James Young D, Loh X . Nanoparticle-Hydrogel Composites: Concept, Design, and Applications of These Promising, Multi-Functional Materials. Adv Sci (Weinh). 2016; 2(1-2):1400010. PMC: 5115280. DOI: 10.1002/advs.201400010. View

Hoffman A . Stimuli-responsive polymers: biomedical applications and challenges for clinical translation. Adv Drug Deliv Rev. 2012; 65(1):10-6. DOI: 10.1016/j.addr.2012.11.004. View

Spizzirri U, Iemma F, Cirillo G, Altimari I, Puoci F, Picci N . Temperature-sensitive hydrogels by graft polymerization of chitosan and N-isopropylacrylamide for drug release. Pharm Dev Technol. 2011; 18(5):1026-34. DOI: 10.3109/10837450.2011.644298. View

Zhao Y, Shi C, Yang X, Shen B, Sun Y, Chen Y . pH- and Temperature-Sensitive Hydrogel Nanoparticles with Dual Photoluminescence for Bioprobes. ACS Nano. 2016; 10(6):5856-63. DOI: 10.1021/acsnano.6b00770. View

10.

Xie B, Jin L, Luo Z, Yu J, Shi S, Zhang Z . An injectable thermosensitive polymeric hydrogel for sustained release of Avastin® to treat posterior segment disease. Int J Pharm. 2015; 490(1-2):375-83. DOI: 10.1016/j.ijpharm.2015.05.071. View

11.

Das D, Ghosh P, Ghosh A, Haldar C, Dhara S, Panda A . Stimulus-Responsive, Biodegradable, Biocompatible, Covalently Cross-Linked Hydrogel Based on Dextrin and Poly(N-isopropylacrylamide) for in Vitro/in Vivo Controlled Drug Release. ACS Appl Mater Interfaces. 2015; 7(26):14338-51. DOI: 10.1021/acsami.5b02975. View

12.

Xu X, Huang Z, Huang Z, Zhang X, He S, Sun X . Injectable, NIR/pH-Responsive Nanocomposite Hydrogel as Long-Acting Implant for Chemophotothermal Synergistic Cancer Therapy. ACS Appl Mater Interfaces. 2017; 9(24):20361-20375. DOI: 10.1021/acsami.7b02307. View

13.

Qasim M, Udomluck N, Chang J, Park H, Kim K . Antimicrobial activity of silver nanoparticles encapsulated in poly--isopropylacrylamide-based polymeric nanoparticles. Int J Nanomedicine. 2018; 13:235-249. PMC: 5757205. DOI: 10.2147/IJN.S153485. View

14.

. Smart polymers for peptide and protein parenteral sustained delivery. Drug Discov Today Technol. 2013; 9(2):e71-e174. DOI: 10.1016/j.ddtec.2012.05.001. View

15.

Palmese L, Thapa R, Sullivan M, Kiick K . Hybrid hydrogels for biomedical applications. Curr Opin Chem Eng. 2019; 24:143-157. PMC: 6914224. DOI: 10.1016/j.coche.2019.02.010. View

16.

Kwon I, Matsuda T . Photo-iniferter-based thermoresponsive block copolymers composed of poly(ethylene glycol) and poly(N-isopropylacrylamide) and chondrocyte immobilization. Biomaterials. 2005; 27(7):986-95. DOI: 10.1016/j.biomaterials.2005.07.038. View

17.

Parisi-Amon A, Mulyasasmita W, Chung C, Heilshorn S . Protein-engineered injectable hydrogel to improve retention of transplanted adipose-derived stem cells. Adv Healthc Mater. 2012; 2(3):428-32. PMC: 3926432. DOI: 10.1002/adhm.201200293. View

18.

Ma C, Shi Y, Pena D, Peng L, Yu G . Thermally Responsive Hydrogel Blends: A General Drug Carrier Model for Controlled Drug Release. Angew Chem Int Ed Engl. 2015; 54(25):7376-80. DOI: 10.1002/anie.201501705. View

19.

Cui H, Liu Y, Cheng Y, Zhang Z, Zhang P, Chen X . In vitro study of electroactive tetraaniline-containing thermosensitive hydrogels for cardiac tissue engineering. Biomacromolecules. 2014; 15(4):1115-23. DOI: 10.1021/bm4018963. View

20.

Darge H, Andrgie A, Tsai H, Lai J . Polysaccharide and polypeptide based injectable thermo-sensitive hydrogels for local biomedical applications. Int J Biol Macromol. 2019; 133:545-563. DOI: 10.1016/j.ijbiomac.2019.04.131. View