Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia

Overview

Journal Dent J (Basel)

Specialty Dentistry

Date 2020 Mar 8

PMID 32143304

Authors

Veronica Oliveira Dias

Daniella Reis Barbosa Martelli

Maria Luiza Santos

Celia Marcia Fernandes Maia

Rodrigo Soares de Andrade

Ricardo D Coletta

Hercilio Martelli Junior

Affiliations

Soon will be listed here.

Abstract

Multiple studies have demonstrated an association between cancer and nonsyndromic oral clefts in different populations. In this study, we assessed the occurrence of nonsyndromic oral clefts in families of patients with acute lymphoblastic leukemia (ALL, = 50) and controls ( = 125). The parents of the patients answered a questionnaire with basic demographic information and family history of nonsyndromic oral clefts in first-degree relatives. Statistical analysis was carried out using Fisher's exact test. In the ALL group, 22 (44%) were male and 28 (56%) were female, and the average age was 13.2 ± 12.2 years. In the control group, 64 (51.2%) were male and 65 were female and the average age was 11.3 ± 10.3 years. Two out of 50 patients (4%) with acute lymphoblastic leukemia had a positive history of nonsyndromic oral clefts, whereas there were no reported occurrences of nonsyndromic oral clefts in the control group (OR: 12.94, 95% CI: 0.61-274.6, = 0.08). Despite the limited population, the frequency of nonsyndromic oral clefts was increased in the first-degree relatives of patients with acute lymphoblastic leukemia. Studies with larger samples and molecular analyses are needed to better understand the possible etiological relationship between cancer and nonsyndromic oral clefts.

References

Kluijt I, Siemerink E, Ausems M, van Os T, de Jong D, Simoes-Correia J . CDH1-related hereditary diffuse gastric cancer syndrome: clinical variations and implications for counseling. Int J Cancer. 2011; 131(2):367-76. DOI: 10.1002/ijc.26398. View

Lima L, Silverio M, Swerts M, de Aquino S, Martelli D, Martelli-Junior H . Frequency of cancer in first-degree relatives of patients with cleft lip and/or palate in the Brazilian population. Braz Dent J. 2013; 24(3):200-3. DOI: 10.1590/0103-6440201302191. View

Anand P, Kunnumakkara A, Kunnumakara A, Sundaram C, Harikumar K, Tharakan S . Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008; 25(9):2097-116. PMC: 2515569. DOI: 10.1007/s11095-008-9661-9. View

Rodrigues K, de Sena M, Roncalli A, Fernandes Ferreira M . Prevalence of orofacial clefts and social factors in Brazil. Braz Oral Res. 2009; 23(1):38-42. DOI: 10.1590/s1806-83242009000100007. View

Dietz A, Pedersen D, Jacobsen R, Wehby G, Murray J, Christensen K . Risk of breast cancer in families with cleft lip and palate. Ann Epidemiol. 2011; 22(1):37-42. PMC: 3237814. DOI: 10.1016/j.annepidem.2011.09.003. View

Kobayashi G, Alvizi L, Sunaga D, Francis-West P, Kuta A, Almada B . Susceptibility to DNA damage as a molecular mechanism for non-syndromic cleft lip and palate. PLoS One. 2013; 8(6):e65677. PMC: 3680497. DOI: 10.1371/journal.pone.0065677. View

Cardoso E, Martelli D, Machado R, Coletta R, de Souza J, Barbosa F . Nonsyndromic cleft lip and palate, gastric cancer and tooth agenesis. Med Oral Patol Oral Cir Bucal. 2017; 23(1):e44-e48. PMC: 5822538. DOI: 10.4317/medoral.22132. View

Hunger S, Mullighan C . Acute Lymphoblastic Leukemia in Children. N Engl J Med. 2015; 373(16):1541-52. DOI: 10.1056/NEJMra1400972. View

Zhu J, Basso O, Hasle H, Winther J, Olsen J, Olsen J . Do parents of children with congenital malformations have a higher cancer risk? A nationwide study in Denmark. Br J Cancer. 2002; 87(5):524-8. PMC: 2376161. DOI: 10.1038/sj.bjc.6600488. View

10.

de Freitas E, Machado R, Santos E, Matos F, Galvao H, Miranda Soares P . Polymorphisms associated with oral clefts as potential susceptibility markers for oral and breast cancer. Arch Oral Biol. 2018; 99:9-14. DOI: 10.1016/j.archoralbio.2018.12.004. View

11.

Bui A, Ayub A, Ahmed M, Taioli E, Taub P . Association Between Cleft Lip and/or Cleft Palate and Family History of Cancer: A Case-Control Study. Ann Plast Surg. 2018; 80(4 Suppl 4):S178-S181. DOI: 10.1097/SAP.0000000000001331. View

12.

Nishi M, Miyake H, Takeda T, Hatae Y . Congenital malformations and childhood cancer. Med Pediatr Oncol. 2000; 34(4):250-4. DOI: 10.1002/(sici)1096-911x(200004)34:4<250::aid-mpo3>3.0.co;2-w. View

13.

Yildirim M, Seymen F, Deeley K, Cooper M, Vieira A . Defining predictors of cleft lip and palate risk. J Dent Res. 2012; 91(6):556-61. DOI: 10.1177/0022034512444928. View

14.

Martelli-Junior H, Porto L, Martelli D, Bonan P, Freitas A, Coletta R . Prevalence of nonsyndromic oral clefts in a reference hospital in the state of Minas Gerais, Brazil, between 2000-2005. Braz Oral Res. 2007; 21(4):314-7. DOI: 10.1590/s1806-83242007000400006. View

15.

Machado R, Moreira H, de Aquino S, Martelli-Junior H, de Almeida Reis S, Persuhn D . Interactions between RAD51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate. Am J Med Genet A. 2015; 170A(2):536-539. DOI: 10.1002/ajmg.a.37281. View

16.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M . Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014; 136(5):E359-86. DOI: 10.1002/ijc.29210. View

17.

Hozyasz K, Mostowska A, Wojcicki P, Lasota A, Offert B, Balcerek A . Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate. Fam Cancer. 2014; 13(3):415-21. PMC: 4164844. DOI: 10.1007/s10689-014-9727-2. View

18.

Goncalves E, Martelli D, Coletta R, Vieira A, Caldeira A, Martelli Jr H . Risk of leukemia in first degree relatives of patients with nonsyndromic cleft lip and palate. Braz Oral Res. 2014; 28:1-3. DOI: 10.1590/1807-3107bor-2014.vol28.0056. View

19.

Steinwachs E, Amos C, Johnston D, Mulliken J, Stal S, Hecht J . Nonsyndromic cleft lip and palate is not associated with cancer or other birth defects. Am J Med Genet. 1999; 90(1):17-24. DOI: 10.1002/(sici)1096-8628(20000103)90:1<17::aid-ajmg4>3.0.co;2-9. View

20.

Meng L, Bian Z, Torensma R, von den Hoff J . Biological mechanisms in palatogenesis and cleft palate. J Dent Res. 2009; 88(1):22-33. DOI: 10.1177/0022034508327868. View