Nonsyndromic Cleft Lip and Palate, Gastric Cancer and Tooth Agenesis

Overview

Journal Med Oral Patol Oral Cir Bucal

Specialty Dentistry

Date 2017 Dec 24

PMID 29274157

Citations 4

Authors

E-F Cardoso

D-R-B Martelli

R-A Machado

R-D Coletta

J-D de Souza

F-T Barbosa

M-F-L de Figueiredo

L-G-V Coelho

H Martelli-Junior

Affiliations

Soon will be listed here.

Abstract

Background: To determine the frequency of nonsyndromic cleft lip and/or palate (NSCL/P) in first-degree relatives and to analyze the prevalence of tooth agenesis in patients with gastric cancer.

Material And Methods: This cross-sectional, observational, case-control study included 798 patients attended at hospital Santa Casa in Montes Claros, Minas Gerais and Alfa Institute of Gastroenterology of the Federal University of the Minas Gerais. Information on basic demographic data and tooth agenesis of both groups and their family history of NSCL/P in first-degree relatives were evaluated. The collected information was stored in a database and analyzed using statistical program SPSS version 21.0 and the values with p<0.05 were considered statistically significant.

Results: Of the 798 patients, 113 (14.16%) consisted of the case group and 685 of the control group (85.84%). Non-Caucasian males were the most affected, although no differences among the groups were detected. Of all participants (n=798), 66 (8.27%) presented tooth agenesis and 25 (3.13%) presented oral cleft in first degree relative.

Conclusions: Our results no found increase in the frequency of tooth agenesis in patients with gastric cancer and in the frequency of NSCL/P in the first-degree relatives of patients with gastric cancer.

Citing Articles

Global Trends and Hotspots in Research on Tooth Agenesis: A 20-Year Bibliometric Analysis.

Xie B, Han Y, Wen X Cureus. 2023; 15(10):e46961.

PMID: 38021739 PMC: 10640767. DOI: 10.7759/cureus.46961.

The genetic factors contributing to the risk of cleft lip-cleft palate and their clinical utility.

Askarian S, Gholami M, Khalili-Tanha G, Tehrani N, Joudi M, Khazaei M Oral Maxillofac Surg. 2022; 27(2):177-186.

PMID: 35426585 DOI: 10.1007/s10006-022-01052-3.

Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia.

Dias V, Martelli D, Santos M, Maia C, de Andrade R, Coletta R Dent J (Basel). 2020; 8(1).

PMID: 32143304 PMC: 7148521. DOI: 10.3390/dj8010023.

Variations in predict risk and prognosis of colorectal cancer.

Otero L, Lacunza E, Vasquez V, Arbelaez V, Cardier F, Gonzalez F BDJ Open. 2019; 5:13.

PMID: 31632692 PMC: 6795800. DOI: 10.1038/s41405-019-0022-z.

References

Lima L, Silverio M, Swerts M, de Aquino S, Martelli D, Martelli-Junior H . Frequency of cancer in first-degree relatives of patients with cleft lip and/or palate in the Brazilian population. Braz Dent J. 2013; 24(3):200-3. DOI: 10.1590/0103-6440201302191. View

Rodrigues K, de Sena M, Roncalli A, Fernandes Ferreira M . Prevalence of orofacial clefts and social factors in Brazil. Braz Oral Res. 2009; 23(1):38-42. DOI: 10.1590/s1806-83242009000100007. View

Kluijt I, Sijmons R, Hoogerbrugge N, Plukker J, de Jong D, van Krieken J . Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance. Fam Cancer. 2012; 11(3):363-9. DOI: 10.1007/s10689-012-9521-y. View

Zhu J, Basso O, Hasle H, Winther J, Olsen J, Olsen J . Do parents of children with congenital malformations have a higher cancer risk? A nationwide study in Denmark. Br J Cancer. 2002; 87(5):524-8. PMC: 2376161. DOI: 10.1038/sj.bjc.6600488. View

de Aquino S, Messetti A, Bagordakis E, Martelli-Junior H, Swerts M, Graner E . Polymorphisms in FGF12, VCL, CX43 and VAX1 in Brazilian patients with nonsyndromic cleft lip with or without cleft palate. BMC Med Genet. 2013; 14:53. PMC: 3660181. DOI: 10.1186/1471-2350-14-53. View

Dixon M, Marazita M, Beaty T, Murray J . Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet. 2011; 12(3):167-78. PMC: 3086810. DOI: 10.1038/nrg2933. View

Bonds J, Pollan-White S, Xiang L, Mues G, DSouza R . Is there a link between ovarian cancer and tooth agenesis?. Eur J Med Genet. 2014; 57(5):235-9. PMC: 4004684. DOI: 10.1016/j.ejmg.2014.02.013. View

Paranaiba L, Coletta R, Swerts M, Quintino R, de Barros L, Martelli-Junior H . Prevalence of Dental Anomalies in Patients With Nonsyndromic Cleft Lip and/or Palate in a Brazilian Population. Cleft Palate Craniofac J. 2011; 50(4):400-5. DOI: 10.1597/11-029. View

Martelli-Junior H, Porto L, Martelli D, Bonan P, Freitas A, Coletta R . Prevalence of nonsyndromic oral clefts in a reference hospital in the state of Minas Gerais, Brazil, between 2000-2005. Braz Oral Res. 2007; 21(4):314-7. DOI: 10.1590/s1806-83242007000400006. View

10.

Windham G, Bjerkedal T, Langmark F . A population-based study of cancer incidence in twins and in children with congenital malformations or low birth weight, Norway, 1967-1980. Am J Epidemiol. 1985; 121(1):49-56. DOI: 10.1093/oxfordjournals.aje.a113982. View

11.

Machado R, Moreira H, de Aquino S, Martelli-Junior H, de Almeida Reis S, Persuhn D . Interactions between RAD51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate. Am J Med Genet A. 2015; 170A(2):536-539. DOI: 10.1002/ajmg.a.37281. View

12.

Goncalves E, Martelli D, Coletta R, Vieira A, Caldeira A, Martelli Jr H . Risk of leukemia in first degree relatives of patients with nonsyndromic cleft lip and palate. Braz Oral Res. 2014; 28:1-3. DOI: 10.1590/1807-3107bor-2014.vol28.0056. View

13.

Steinwachs E, Amos C, Johnston D, Mulliken J, Stal S, Hecht J . Nonsyndromic cleft lip and palate is not associated with cancer or other birth defects. Am J Med Genet. 1999; 90(1):17-24. DOI: 10.1002/(sici)1096-8628(20000103)90:1<17::aid-ajmg4>3.0.co;2-9. View

14.

Dietz A, Pedersen D, Jacobsen R, Wehby G, Murray J, Christensen K . Risk of breast cancer in families with cleft lip and palate. Ann Epidemiol. 2011; 22(1):37-42. PMC: 3237814. DOI: 10.1016/j.annepidem.2011.09.003. View

15.

Filho M, Santos L, Martelli D, Silveira M, Esteves da Silva M, de Barros L . Taurodontism in patients with nonsyndromic cleft lip and palate in a Brazilian population: a case control evaluation with panoramic radiographs. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120(6):744-50. DOI: 10.1016/j.oooo.2015.08.005. View

16.

Lindor N, Win A, Gallinger S, Daftary D, Thibodeau S, Silva R . Colorectal cancer and self-reported tooth agenesis. Hered Cancer Clin Pract. 2014; 12(1):7. PMC: 3975307. DOI: 10.1186/1897-4287-12-7. View

17.

Gonzalez C, Sala N, Rokkas T . Gastric cancer: epidemiologic aspects. Helicobacter. 2013; 18 Suppl 1:34-8. DOI: 10.1111/hel.12082. View

18.

Lammi L, Arte S, Somer M, Jarvinen H, Lahermo P, Thesleff I . Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet. 2004; 74(5):1043-50. PMC: 1181967. DOI: 10.1086/386293. View

19.

Chalothorn L, Beeman C, Ebersole J, Kluemper G, Hicks E, Kryscio R . Hypodontia as a risk marker for epithelial ovarian cancer: a case-controlled study. J Am Dent Assoc. 2008; 139(2):163-9. DOI: 10.14219/jada.archive.2008.0132. View

20.

Machado R, de Freitas E, de Aquino S, Martelli D, Swerts M, de Almeida Reis S . Clinical relevance of breast and gastric cancer-associated polymorphisms as potential susceptibility markers for oral clefts in the Brazilian population. BMC Med Genet. 2017; 18(1):39. PMC: 5379638. DOI: 10.1186/s12881-017-0390-y. View