Roles of Pattern Recognition Receptors in Diabetic Nephropathy

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2020 Mar 6

PMID 32133797

Citations 7

Authors

Zhi-Feng Zhou

Lei Jiang

Qing Zhao

Yu Wang

Jing Zhou

Qin-Kai Chen

Jin-Lei Lv

Affiliations

Soon will be listed here.

Abstract

Diabetic nephropathy (DN) is currently the most common complication of diabetes. It is considered to be one of the leading causes of end-stage renal disease (ESRD) and affects many diabetic patients. The pathogenesis of DN is extremely complex and has not yet been clarified; however, in recent years, increasing evidence has shown the important role of innate immunity in DN pathogenesis. Pattern recognition receptors (PRRs) are important components of the innate immune system and have a significant impact on the occurrence and development of DN. In this review, we classify PRRs into secretory, endocytic, and signal transduction PRRs according to the relationship between the PRRs and subcellular compartments. PRRs can recognize related pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), thus triggering a series of inflammatory responses, promoting renal fibrosis, and finally causing renal impairment. In this review, we describe the proposed role of each type of PRRs in the development and progression of DN.

Citing Articles

Advancements and challenges in brain cancer therapeutics.

Bai F, Deng Y, Li L, Lv M, Razzokov J, Xu Q Exploration (Beijing). 2024; 4(6):20230177.

PMID: 39713205 PMC: 11655316. DOI: 10.1002/EXP.20230177.

HMGN1 down-regulation in the diabetic kidney attenuates tubular cells injury and protects against renal inflammation via suppressing MCP-1 and KIM-1 expression through TLR4.

Yu J, Da J, Yu F, Yuan J, Zha Y J Endocrinol Invest. 2024; 47(4):1015-1027.

PMID: 38409569 DOI: 10.1007/s40618-023-02292-0.

Jiang P, Yao C, Guo D Acta Pharm Sin B. 2024; 14(1):38-66.

PMID: 38239236 PMC: 10793104. DOI: 10.1016/j.apsb.2023.11.006.

Male Akita mice develop signs of bladder underactivity independent of NLRP3 as a result of a decrease in neurotransmitter release from efferent neurons.

Hughes Jr F, Allkanjari A, Odom M, Mulcrone J, Jin H, Purves J Am J Physiol Renal Physiol. 2023; 325(1):F61-F72.

PMID: 37167271 PMC: 10292983. DOI: 10.1152/ajprenal.00284.2022.

Prospective Analysis of B Lymphocyte Subtypes, before and after Initiation of Dialysis, in Patients with End-Stage Renal Disease.

Daikidou D, Lioulios G, Sampani E, Xochelli A, Nikolaidou V, Moysidou E Life (Basel). 2023; 13(4).

PMID: 37109388 PMC: 10146774. DOI: 10.3390/life13040860.

References

Gysler S, Mulla M, Guerra M, Brosens J, Salmon J, Chamley L . Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8. Mol Hum Reprod. 2016; 22(7):465-74. PMC: 4941806. DOI: 10.1093/molehr/gaw027. View

Thakur V, Nargis S, Gonzalez M, Pradhan S, Terreros D, Chattopadhyay M . Role of Glycyrrhizin in the Reduction of Inflammation in Diabetic Kidney Disease. Nephron. 2017; 137(2):137-147. DOI: 10.1159/000477820. View

Lu L, Peng W, Wang W, Wang L, Chen Q, Shen W . Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats. J Zhejiang Univ Sci B. 2011; 12(8):652-9. PMC: 3150719. DOI: 10.1631/jzus.B1101004. View

Ye Y, Chen Q, Li J, Jin L, Zheng J, Li X . CXCL16 deficiency attenuates diabetic nephropathy through decreasing oxidative stress and inflammation. Biochem Biophys Res Commun. 2017; 491(3):848-854. DOI: 10.1016/j.bbrc.2017.05.013. View

Zhao L, Wu F, Jin L, Lu T, Yang L, Pan X . Serum CXCL16 as a novel marker of renal injury in type 2 diabetes mellitus. PLoS One. 2014; 9(1):e87786. PMC: 3906379. DOI: 10.1371/journal.pone.0087786. View

Zheng S, Coventry S, Cai L, Powell D, Jala V, Haribabu B . Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice. J Diabetes Res. 2016; 2016:5362506. PMC: 4699014. DOI: 10.1155/2016/5362506. View

Qiao Y, Tian X, Men L, Li S, Chen Y, Xue M . Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy. Mol Med Rep. 2018; 18(2):1995-2008. PMC: 6072182. DOI: 10.3892/mmr.2018.9164. View

Janowski A, Kolb R, Zhang W, Sutterwala F . Beneficial and Detrimental Roles of NLRs in Carcinogenesis. Front Immunol. 2013; 4:370. PMC: 3824244. DOI: 10.3389/fimmu.2013.00370. View

Hou Y, Wu M, Wei J, Ren Y, Du C, Wu H . CD36 is involved in high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells. Biochem Biophys Res Commun. 2015; 468(1-2):281-6. DOI: 10.1016/j.bbrc.2015.10.112. View

10.

Lin M, Tang S . Toll-like receptors: sensing and reacting to diabetic injury in the kidney. Nephrol Dial Transplant. 2013; 29(4):746-54. DOI: 10.1093/ndt/gft446. View

11.

Hisano S, Matsushita M, Fujita T, Takeshita M, Iwasaki H . Activation of the lectin complement pathway in post-streptococcal acute glomerulonephritis. Pathol Int. 2007; 57(6):351-7. DOI: 10.1111/j.1440-1827.2007.02107.x. View

12.

Wang H, Wang S, Chiufai K, Wang Q, Cheng X . Umbelliferone ameliorates renal function in diabetic nephropathy rats through regulating inflammation and TLR/NF-κB pathway. Chin J Nat Med. 2019; 17(5):346-354. DOI: 10.1016/S1875-5364(19)30040-8. View

13.

Gutwein P, Abdel-Bakky M, Doberstein K, Schramme A, Beckmann J, Schaefer L . CXCL16 and oxLDL are induced in the onset of diabetic nephropathy. J Cell Mol Med. 2009; 13(9B):3809-25. PMC: 4516529. DOI: 10.1111/j.1582-4934.2009.00761.x. View

14.

Ostergaard J, Bjerre M, RamachandraRao S, Sharma K, Nyengaard J, Hansen T . Mannan-binding lectin in diabetic kidney disease: the impact of mouse genetics in a type 1 diabetes model. Exp Diabetes Res. 2012; 2012:678381. PMC: 3356895. DOI: 10.1155/2012/678381. View

15.

Ostergaard J, Thiel S, Hoffmann-Petersen I, Hovind P, Parving H, Tarnow L . Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes. Diabetes Metab Res Rev. 2017; 33(5). DOI: 10.1002/dmrr.2895. View

16.

Axelgaard E, Ostergaard J, Thiel S, Hansen T . Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin. J Diabetes Res. 2017; 2017:6368780. PMC: 5350336. DOI: 10.1155/2017/6368780. View

17.

Fernandes-Alnemri T, Yu J, Datta P, Wu J, Alnemri E . AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 2009; 458(7237):509-13. PMC: 2862225. DOI: 10.1038/nature07710. View

18.

McKnight A, Duffy S, Maxwell A . Genetics of diabetic nephropathy: a long road of discovery. Curr Diab Rep. 2015; 15(7):41. DOI: 10.1007/s11892-015-0610-9. View

19.

Komada T, Chung H, Lau A, Platnich J, Beck P, Benediktsson H . Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD. J Am Soc Nephrol. 2018; 29(4):1165-1181. PMC: 5875955. DOI: 10.1681/ASN.2017080863. View

20.

Shang J, Wan Q, Wang X, Duan Y, Wang Z, Wei X . Identification of NOD2 as a novel target of RNA-binding protein HuR: evidence from NADPH oxidase-mediated HuR signaling in diabetic nephropathy. Free Radic Biol Med. 2014; 79:217-27. DOI: 10.1016/j.freeradbiomed.2014.12.013. View