Genetics of Diabetic Nephropathy: a Long Road of Discovery

Overview

Journal Curr Diab Rep

Publisher Current Science

Specialty Endocrinology

Date 2015 May 15

PMID 25971618

Citations 14

Authors

Amy Jayne McKnight

Seamus Duffy

Alexander P Maxwell

Affiliations

Soon will be listed here.

Abstract

The global prevalence of diabetic nephropathy is rising in parallel with the increasing incidence of diabetes in most countries. Unfortunately, up to 40 % of persons diagnosed with diabetes may develop kidney complications. Diabetic nephropathy is associated with substantially increased risks of cardiovascular disease and premature mortality. An inherited susceptibility to diabetic nephropathy exists, and progress is being made unravelling the genetic basis for nephropathy thanks to international research collaborations, shared biological resources and new analytical approaches. Multiple epidemiological studies have highlighted the clinical heterogeneity of nephropathy and the need for better phenotyping to help define important subgroups for analysis and increase the power of genetic studies. Collaborative genome-wide association studies for nephropathy have reported unique genes, highlighted novel biological pathways and suggested new disease mechanisms, but progress towards clinically relevant risk prediction models for diabetic nephropathy has been slow. This review summarises the current status, recent developments and ongoing challenges elucidating the genetics of diabetic nephropathy.

Citing Articles

Differential Methylation of Telomere-Related Genes Is Associated with Kidney Disease in Individuals with Type 1 Diabetes.

Hill C, Duffy S, Kettyle L, McGlynn L, Sandholm N, Salem R Genes (Basel). 2023; 14(5).

PMID: 37239390 PMC: 10217816. DOI: 10.3390/genes14051029.

Harnessing Genomic Analysis to Explore the Role of Telomeres in the Pathogenesis and Progression of Diabetic Kidney Disease.

Hill C, Duffy S, Coulter T, Maxwell A, McKnight A Genes (Basel). 2023; 14(3).

PMID: 36980881 PMC: 10048490. DOI: 10.3390/genes14030609.

Clinical Predictors and Long-term Impact of Acute Kidney Injury on Progression of Diabetic Kidney Disease in Chinese Patients With Type 2 Diabetes.

Jiang G, Luk A, Tam C, Ozaki R, Lim C, Chow E Diabetes. 2022; 71(3):520-529.

PMID: 35043149 PMC: 8893937. DOI: 10.2337/db21-0694.

A Custom Target Next-Generation Sequencing 70-Gene Panel and Replication Study to Identify Genetic Markers of Diabetic Kidney Disease.

Mota-Zamorano S, Gonzalez L, Robles N, Valdivielso J, Cancho B, Lopez-Gomez J Genes (Basel). 2021; 12(12).

PMID: 34946941 PMC: 8702126. DOI: 10.3390/genes12121992.

Revisiting Experimental Models of Diabetic Nephropathy.

Giralt-Lopez A, Molina-Van den Bosch M, Vergara A, Garcia-Carro C, Seron D, Jacobs-Cacha C Int J Mol Sci. 2020; 21(10).

PMID: 32438732 PMC: 7278948. DOI: 10.3390/ijms21103587.

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