Brain Resting-State Network Alterations Associated With Crohn's Disease

Overview

Journal Front Neurol

Specialty Neurology

Date 2020 Mar 6

PMID 32132964

Citations 24

Authors

Jennifer Kornelsen

Alyssia Wilson

Jennifer S Labus

Kelcie Witges

Emeran A Mayer

Charles N Bernstein

Affiliations

Soon will be listed here.

Abstract

Inflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain structure and in functional connectivity (FC) of brain regions in 35 participants with Crohn's disease (CD) and 21 healthy controls (HC). Voxel-based morphometry (VBM) analysis was performed to contrast CD and HC structural images. Region of interest (ROI) analyses were run to assess FC for resting-state network nodes. Independent component analysis (ICA) identified whole brain differences in FC associated with resting-state networks. Though no structural differences were found, ROI analyses showed increased FC between the frontoparietal (FP) network and salience network (SN), and decreased FC between nodes of the default mode network (DMN). ICA results revealed changes involving cerebellar (CER), visual (VIS), and SN components. Differences in FC associated with sex were observed for both ROI analysis and ICA. Taken together, these changes are consistent with an influence of CD on the brain and serve to direct future research hypotheses.

Citing Articles

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