Analysis of Serum Inflammatory Mediators in Type 2 Diabetic Patients and Their Influence on Renal Function

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2020 Mar 5

PMID 32130282

Citations 13

Authors

Liliane Silvano Araujo

Marcos Vinicius da Silva

Crislaine Aparecida da Silva

Maria de Fatima Borges

Heloisa Marcelina da Cunha Palhares

Laura Penna Rocha

Rosana Rosa Miranda Correa

Virmondes Rodrigues Junior

Marlene Antonia Dos Reis

Juliana Reis Machado

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the serum concentrations of inflammatory mediators in patients with type 2 diabetes mellitus (T2DM) with or without renal alteration (RA) function.

Methods: Serum samples from 76 patients with T2DM and 24 healthy individuals were selected. Patients with T2DM were divided into two groups according to eGFR (> or < 60mL/min/1.73m2). Cytokines, chemokines and adipokines levels were evaluated using the Multiplex immunoassay and ELISA.

Results: TNFR1 and leptin were higher in the T2DM group with RA than in the T2DM group without RA and control group. All patients with T2DM showed increased resistin, IL-8, and MIP-1α compared to the control group. Adiponectin were higher and IL-4 decreased in the T2DM group with RA compared to the control group. eGFR positively correlated with IL-4 and negatively with TNFR1, TNFR2, and leptin in patients with T2DM. In the T2DM group with RA, eGFR was negatively correlated with TNFR1 and resistin. TNFR1 was positively correlated with resistin and leptin, as well as resistin with IL-8 and leptin.

Conclusion: Increased levels of TNFR1, adipokines, chemokines and decrease of IL-4 play important role in the inflammatory process developed in T2DM and decreased renal function. We also suggest that TNFR1 is a strong predictor of renal dysfunction in patients with T2DM.

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