Long Noncoding RNAs: New Insights in Modulating Mammalian Spermatogenesis

Overview

Journal J Anim Sci Biotechnol

Publisher Biomed Central

Date 2020 Mar 5

PMID 32128162

Citations 14

Authors

Bahlibi Weldegebriall Sahlu

Shanjiang Zhao

Xiuge Wang

Saqib Umer

Huiying Zou

Jinming Huang

Huabin Zhu

Affiliations

Soon will be listed here.

Abstract

Spermatogenesis is a complex differentiating developmental process in which undifferentiated spermatogonial germ cells differentiate into spermatocytes, spermatids, and finally, to mature spermatozoa. This multistage developmental process of spermatogenesis involves the expression of many male germ cell-specific long noncoding RNAs (lncRNAs) and highly regulated and specific gene expression. LncRNAs are a recently discovered large class of noncoding cellular transcripts that are still relatively unexplored. Only a few of them have post-meiotic; however, lncRNAs are involved in many cellular biological processes. The expression of lncRNAs is biologically relevant in the highly dynamic and complex program of spermatogenesis and has become a research focus in recent genome studies. This review considers the important roles and novel regulatory functions whereby lncRNAs modulate mammalian spermatogenesis.

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