The Activation of BAFF/APRIL System in Spleen and Lymph Nodes of Plasmodium Falciparum Infected Patients

Overview

Journal Sci Rep

Specialty Science

Date 2020 Mar 4

PMID 32123265

Citations 6

Authors

Wilanee Dechkhajorn

Surachet Benjathummarak

Supattra Glaharn

Urai Chaisri

Parnpen Viriyavejakul

Yaowapa Maneerat

Affiliations

Soon will be listed here.

Abstract

Previous studies have reported activation of the B cell-activating factor (BAFF)/a proliferation-inducing ligand (APRIL) system in T independent immunity against malaria infection. Plasmodium falciparum (P. falciparum) infected animal model is not feasible. Therefore, little is known about the occurrence of BAFF/APRIL system and changes in falciparum lymphoid tissues. This study aimed to investigate the expression of BAFF/APRIL system components in lymphoid tissues from P. falciparum infected patients. Spleen and lymph node samples from 14 patients were collected at autopsy. Normal spleens and bacterially infected tonsils served as controls. The protein and/or mRNA expression of BAFF/APRIL and their cognate receptors, BAFF-R, TACI and BCMA, were determined by immunohistochemistry and RT-qPCR, respectively. The spleens of the patients exhibited significantly higher BAFF-R protein expression than normal spleens. Although without appropriate control, BCMA protein was markedly observed only in the lymph nodes. BAFF and BCMA mRNA levels were also significantly elevated in the spleen tissues of the patients compared with normal spleens. The overall BAFF-R protein levels in the lymphoid tissues of the patients correlated positively with parasitaemia. These findings are the first to confirm that BAFF/APRIL system activation in lymphoid tissues and is positively correlated with the parasitaemia levels in falciparum malaria.

Citing Articles

Proof-of-concept study evaluating humoral primary immunodeficiencies via CJ:KREC ratio and serum BAFF level.

Ochfeld E, Khojah A, Marin W, Morgan G, Pachman L Sci Rep. 2024; 14(1):14356.

PMID: 38906917 PMC: 11192915. DOI: 10.1038/s41598-024-64942-4.

The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria.

Boyle M, Engwerda C, Jagannathan P Nat Rev Immunol. 2024; 24(9):637-653.

PMID: 38862638 PMC: 11688169. DOI: 10.1038/s41577-024-01041-5.

Immunomodulatory effects of BAFF and APRIL cytokines in post-pulmonary infection lung cancer: Implications for drug resistance and progression.

Alturaiki W Saudi Med J. 2024; 45(3):223-229.

PMID: 38438201 PMC: 11115388. DOI: 10.15537/smj.2024.45.3.20230873.

A PRoliferation-Inducing Ligand (APRIL) in the Pathogenesis of Immunoglobulin A Nephropathy: A Review of the Evidence.

Mathur M, Chan T, Oh K, Kooienga L, Zhuo M, Pinto C J Clin Med. 2023; 12(21).

PMID: 37959392 PMC: 10650434. DOI: 10.3390/jcm12216927.

Distinct binding mode of BAFF antagonist antibodies belimumab and tabalumab, analyzed by computer simulation.

Jiang Y, Sun J, Wei J J Mol Model. 2022; 28(10):292.

PMID: 36063219 DOI: 10.1007/s00894-022-05142-7.

References

Claudio E, Brown K, Park S, Wang H, Siebenlist U . BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells. Nat Immunol. 2002; 3(10):958-65. DOI: 10.1038/ni842. View

Ng L, Sutherland A, Newton R, Qian F, Cachero T, Scott M . B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol. 2004; 173(2):807-17. DOI: 10.4049/jimmunol.173.2.807. View

Schneider P . The role of APRIL and BAFF in lymphocyte activation. Curr Opin Immunol. 2005; 17(3):282-9. DOI: 10.1016/j.coi.2005.04.005. View

Litinskiy M, Nardelli B, Hilbert D, He B, Schaffer A, Casali P . DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol. 2002; 3(9):822-9. PMC: 4621779. DOI: 10.1038/ni829. View

Dillon S, Gross J, Ansell S, Novak A . An APRIL to remember: novel TNF ligands as therapeutic targets. Nat Rev Drug Discov. 2006; 5(3):235-46. DOI: 10.1038/nrd1982. View

Hatzoglou A, Roussel J, Bourgeade M, Rogier E, Madry C, Inoue J . TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. J Immunol. 2000; 165(3):1322-30. DOI: 10.4049/jimmunol.165.3.1322. View

Notas G, Alexaki V, Kampa M, Pelekanou V, Charalampopoulos I, Sabour-Alaoui S . APRIL binding to BCMA activates a JNK2-FOXO3-GADD45 pathway and induces a G2/M cell growth arrest in liver cells. J Immunol. 2012; 189(10):4748-58. DOI: 10.4049/jimmunol.1102891. View

Kimberley F, Medema J, Hahne M . APRIL in B-cell malignancies and autoimmunity. Results Probl Cell Differ. 2009; 49:161-82. DOI: 10.1007/400_2008_19. View

Craxton A, Magaletti D, Ryan E, Clark E . Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF. Blood. 2003; 101(11):4464-71. DOI: 10.1182/blood-2002-10-3123. View

10.

Ittah M, Miceli-Richard C, Gottenberg J, Sellam J, Eid P, Lebon P . Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR- and type-I IFN-dependent and -independent pathways. Eur J Immunol. 2008; 38(4):1058-64. DOI: 10.1002/eji.200738013. View

11.

Buffet P, Safeukui I, Deplaine G, Brousse V, Prendki V, Thellier M . The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology. Blood. 2010; 117(2):381-92. PMC: 3031473. DOI: 10.1182/blood-2010-04-202911. View

12.

Del Portillo H, Ferrer M, Brugat T, Martin-Jaular L, Langhorne J, Lacerda M . The role of the spleen in malaria. Cell Microbiol. 2011; 14(3):343-55. DOI: 10.1111/j.1462-5822.2011.01741.x. View

13.

Chu V, Enghard P, Riemekasten G, Berek C . In vitro and in vivo activation induces BAFF and APRIL expression in B cells. J Immunol. 2007; 179(9):5947-57. DOI: 10.4049/jimmunol.179.9.5947. View

14.

Ju S, Zhang D, Wang Y, Ni H, Kong X, Zhong R . Correlation of the expression levels of BLyS and its receptors mRNA in patients with systemic lupus erythematosus. Clin Biochem. 2006; 39(12):1131-7. DOI: 10.1016/j.clinbiochem.2006.09.010. View

15.

Kang J, Yoon Y, Ahn J, Kim S, Kim K, Kim H . B cell-activating factor is a novel diagnosis parameter for asthma. Int Arch Allergy Immunol. 2006; 141(2):181-8. DOI: 10.1159/000094897. View

16.

Mackay F, Schneider P . TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties. Cytokine Growth Factor Rev. 2008; 19(3-4):263-76. DOI: 10.1016/j.cytogfr.2008.04.006. View

17.

Morel J, Roubille C, Planelles L, Rocha C, Fernandez L, Lukas C . Serum levels of tumour necrosis factor family members a proliferation-inducing ligand (APRIL) and B lymphocyte stimulator (BLyS) are inversely correlated in systemic lupus erythematosus. Ann Rheum Dis. 2008; 68(6):997-1002. DOI: 10.1136/ard.2008.090928. View

18.

Woo Y, Yoon B, Jhun J, Oh H, Min S, Cho M . Regulation of B cell activating factor (BAFF) receptor expression by NF-ΚB signaling in rheumatoid arthritis B cells. Exp Mol Med. 2011; 43(6):350-7. PMC: 3128913. DOI: 10.3858/emm.2011.43.6.038. View

19.

Kern C, Cornuel J, Billard C, Tang R, Rouillard D, Stenou V . Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. Blood. 2003; 103(2):679-88. DOI: 10.1182/blood-2003-02-0540. View

20.

He B, Xu W, Santini P, Polydorides A, Chiu A, Estrella J . Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity. 2007; 26(6):812-26. DOI: 10.1016/j.immuni.2007.04.014. View