Inhibition of Livin Overcomes Radioresistance in Nasopharyngeal Carcinoma Cells

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2020 Mar 3

PMID 32119704

Citations 4

Authors

Fei Ma

Xia Gu

Jiang-Qi Liu

Li-Hua Mo

Gui Yang

Xiao-Rui Geng

Zhi-Qiang Liu

Zhi-Gang Liu

Ping-Chang Yang

Affiliations

Soon will be listed here.

Abstract

Background And Aims: Radiotherapy is one of the major remedies for the treatment of cancer, including nasopharyngeal carcinoma (NPC). Radioresistance occurs very often in target cells that is a large drawback in cancer treated with radiotherapy. Livin involves the over-growth of cancer cells. This study aims to investigate the role of livin in the radioresistance formation in NPC cells.

Methods: NPC cell lines were exposed to small doses of irradiation to establish a cell model of radioresistance, in which the role of livin in the development of radioresistance was evaluated.

Results: The expression of livin was observed in NPC cells, which was significantly increased after exposing to small doses of irradiation. A negative correlation was detected between livin and Fas expression in NPC cells. Livin formed a complex with heat shock factor-1 (HSF1, the transcription factor of Fas) in NPC cells after irradiation, which sped up ubiquitination of HSF1. Livin was involved in suppressing Fas expression in NPC cells with radioresistance. Exposure to livin inhibitors prevented radioresistance development and overcame the established radioresistance in NPC cells.

Conclusions: Livin expression in NPC cells plays a critical role in the development of radioresistance. Depletion of livin increases the sensitiveness of NPC cells to irradiation. Target therapy against livin may have the translational potential for the treatment of NPC.

Citing Articles

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Livin in synergy with Ras induces and sustains corticosteroid resistance in the airway mucosa.

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