Apoptosis: A Target for Anticancer Therapy

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Feb 3

PMID 29393886

Citations 548

Authors

Claire M Pfeffer

Amareshwar T K Singh

Affiliations

Soon will be listed here.

Abstract

Apoptosis, the cell's natural mechanism for death, is a promising target for anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to carry out apoptosis through the cleavage of hundreds of proteins. In cancer, the apoptotic pathway is typically inhibited through a wide variety of means including overexpression of antiapoptotic proteins and under-expression of proapoptotic proteins. Many of these changes cause intrinsic resistance to the most common anticancer therapy, chemotherapy. Promising new anticancer therapies are plant-derived compounds that exhibit anticancer activity through activating the apoptotic pathway.

Citing Articles

Molecular Docking of Lactoferrin with Apoptosis-Related Proteins Insights into Its Anticancer Mechanism.

Angel-Lerma L, Carrillo-Campos J, Sianez-Estrada L, Siqueiros-Cendon T, Leon-Flores D, Espinoza-Sanchez E Int J Mol Sci. 2025; 26(5).

PMID: 40076649 PMC: 11899785. DOI: 10.3390/ijms26052023.

Development and Characterization of Three Novel FGFR Inhibitor Resistant Cervical Cancer Cell Lines to Help Drive Cervical Cancer Research.

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Imipramine-induced Apoptosis and Metastasis Inhibition in Human Bladder Cancer T24 Cells Through EGFR/ERK/NF-κB Pathway Suppression.

Wang W, Liu Y, Lo T, Hsu F, Chiang C In Vivo. 2025; 39(2):669-682.

PMID: 40010952 PMC: 11884455. DOI: 10.21873/invivo.13871.

The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53-MDM2 Modulation.

Girgis A, Zhao Y, Nkosi A, Ismail N, Bekheit M, Aboshouk D Pharmaceuticals (Basel). 2025; 18(2).

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