Characteristic Cytokine Profiles of Aqueous Humor in Glaucoma Secondary to Sturge-Weber Syndrome

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2020 Mar 3

PMID 32117217

Citations 8

Authors

Cheng Peng

Yue Wu

Xuming Ding

Di Chen

Changjuan Zeng

Li Xu

Wenyi Guo

Affiliations

Soon will be listed here.

Abstract

Patients with Sturge-Weber syndrome (SWS) are susceptible to ocular complications, and among them, glaucoma is one of the most frequent forms. In current study, we utilized multiplex human cytokine antibody array to simultaneously measure the concentration of 40 cytokines in aqueous humor (AH) of patients with SWS-induced glaucoma (SG), or from patients with senile cataract as controls. Compared with the control group, levels of interleukin (IL)-12p40, macrophage inflammatory protein (MIP)-1d, tumor necrosis factor-alpha (TNF-a), IL-5, IL-7, interleukin-6 receptor (IL-6R), and B lymphocyte chemoattractant (BLC) in AH were significantly higher in SG group. Samples from SG patients displayed significantly lower levels of MIP-1b, IL-6, MIP-1a, and monocyte chemoattractant protein (MCP)-1 than controls. Further analysis showed that IL-7, MIP-1a, TNF-a were positively correlated with intraocular pressure (IOP) in patients with early-onset SG. Moreover, IL-12p40 was negatively correlated with age in patients with SG. These cytokines may make contributions to the immunopathogenesis or progression of glaucoma in patients with SWS.

Citing Articles

Evaluating the long-term biological stability of cytokine biomarkers in ocular fluid samples.

Felfeli T, Park J, Nestor B, Altomare F, Rai A, Mandelcorn E BMJ Open Ophthalmol. 2023; 8(1).

PMID: 38081779 PMC: 10729172. DOI: 10.1136/bmjophth-2023-001346.

Aqueous Humor Cytokine Profile in Primary Congenital Glaucoma.

Oribio-Quinto C, Burgos-Blasco B, Perez-Garcia P, Espino-Paisan L, Sarria B, Fernandez-Vigo J J Clin Med. 2023; 12(9).

PMID: 37176583 PMC: 10178937. DOI: 10.3390/jcm12093142.

Short and long-term effect of dexamethasone on the transcriptome profile of primary human trabecular meshwork cells in vitro.

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Tezel G Expert Rev Proteomics. 2021; 18(10):911-924.

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