Endoplasmic Reticulum Stress and Pulmonary Hypertension

Overview

Journal Pulm Circ

Publisher Wiley

Specialty Pulmonary Medicine

Date 2020 Feb 29

PMID 32110387

Citations 7

Authors

Yanan Hu

Wenhao Yang

Liang Xie

Tao Liu

Hanmin Liu

Bin Liu

Affiliations

Soon will be listed here.

Abstract

Pulmonary hypertension is a fatal disease of which pulmonary vasculopathy is the main pathological feature resulting in the mean pulmonary arterial pressure higher than 25 mmHg. Moreover, pulmonary hypertension remains a tough problem with unclear molecular mechanisms. There have been dozens of studies about endoplasmic reticulum stress during the onset of pulmonary hypertension in patients, suggesting that endoplasmic reticulum stress may have a critical effect on the pathogenesis of pulmonary hypertension. The review aims to summarize the rationale to elucidate the role of endoplasmic reticulum stress in pulmonary hypertension. Started by reviewing the mechanisms responsible for the unfolded protein response following endoplasmic reticulum stress, the potential link between endoplasmic reticulum stress and pulmonary hypertension were introduced, and the contributions of endoplasmic reticulum stress to different vascular cells, mitochondria, and inflammation were described, and finally the potential therapies of attenuating endoplasmic reticulum stress for pulmonary hypertension were discussed.

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