Molecular Pathogenesis of Pulmonary Arterial Hypertension

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2008 Jul 4

PMID 18596905

Citations 168

Authors

Marlene Rabinovitch

Affiliations

Soon will be listed here.

Abstract

Recent investigations have suggested that it might be possible to reverse the pathology of pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal despite current treatments including i.v. prostacyclin. This review will address the cellular and molecular processes implicated in clinical, genetic, and experimental studies as underlying the pulmonary vascular abnormalities associated with PAH. Emerging treatments are aimed at inducing apoptosis of abnormal vascular cells that obstruct blood flow and at promoting regeneration of "lost" distal vasculature.

Citing Articles

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